Synthetic Uniform Polymers and Their Use for Understanding Fundamental Problems in Polymer Chemistry

Hatäda, Koichi; Kitayama, Tatsuki; Ute, Koichi; Nishiura, Takafumi

doi:10.1002/marc.200400074

Cited by 26 publications

(12 citation statements)

References 127 publications

(508 reference statements)

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“…Other polymerization procedures including ATRP, SET‐LRP and PET‐RAFT will provide a comparable or superior library of multifunctional discrete oligomers. Other separation procedures such as normal‐phase, ion‐exchange, size exclusion and affinity chromatography will be applicable depending on the properties of functional groups. Since both polymerization and purification processes can be scaled up with ease, this process will become a promising route to inexpensive and physiochemically stable substitutes for biomacromolecular ligands such as RNA, DNA, and peptide aptamers.…”

Section: Methodsmentioning

confidence: 99%

Homogeneous Oligomeric Ligands Prepared via Radical Polymerization that Recognize and Neutralize a Target Peptide

et al. 2019

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Abiotic ligands that bind to specific biomolecules have attracted attention as substitutes for biomolecular ligands, such as antibodies and aptamers. Radical polymerization enables the production of robust polymeric ligands from inexpensive functional monomers. However, little has been reported about the production of monodispersed polymeric ligands. Herein, we present homogeneous ligands prepared via radical polymerization that recognize epitope sequences on a target peptide and neutralize the toxicity of the peptide. Taking advantage of controlled radical polymerization and separation, a library of multifunctional oligomers with discrete numbers of functional groups was prepared. Affinity screening revealed that the sequence specificity of the oligomer ligands strongly depended on the number of functional groups. The process reported here will become a general step for the development of abiotic ligands that recognize specific peptide sequences.

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Section: Methodsmentioning

confidence: 99%

Homogeneous Oligomeric Ligands Prepared via Radical Polymerization that Recognize and Neutralize a Target Peptide

et al. 2019

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“…While it is not yet practical to prepare synthetic polymers to the same high degree of uniformity as proteins, nature also effectively utilizes many polymers with lower degrees of uniformity (e.g., polysaccharides, poly(amino acids), polyhydroxyalkanoates). In recent years it has become possible to prepare with practical experimental protocols sufficient quantities of polymers that display many aspects of uniformity [64][65][66][67][68][69][70][71][72][73][74][75][76][77].…”

Section: Application Of Modern Methods Of Molecular Design and Procesmentioning

confidence: 99%

Challenges for Natural Monomers and Polymers: Novel Design Strategies and Engineering to Develop Advanced Polymers

Pillai

2010

Designed Monomers and Polymers

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The last century witnessed the emergence of polymer science and technology that enabled the generation of knowledge and techniques to control the size, shape, structure, properties and functions of polymers to generate polymers with unprecedented properties and functions. There have been many attempts to apply this information to natural monomers and polymers to achieve the desired property profiles with varying degrees of success which have given/are giving it a new outlook as a possible alternative source for the production of polymers. Novel concepts and techniques such as 'bio-inspired' polymer design, 'synthetically-inspired' material development, etc., are contributing to the development of natural monomers and polymers as a sustainable resource to generate a knowledge-based design methodology to meet the vastly developing requirements of modern materials. This paper reviews these emerging concepts and techniques that integrate materials synthesis, process and manufacturing options with eco efficiency.

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“…On the basis of the fundamental study of 'nonspecific' protein-particle interactions, strategies for the design of NPs that strongly interact with specific molecules have been developed. Further fusion of the approaches of supramolecular chemistry, 73 stereocontrolled polymerization, 74 topology control 75 and living polymerization 76 is expected to enable future development of uniform polymer ligands 77,78 as 'monoclonal plastic antibodies, 79 that more strongly and specifically recognize target biomacromolecules.…”

Section: Prospectivementioning

confidence: 99%

Interaction between synthetic particles and biomacromolecules: fundamental study of nonspecific interaction and design of nanoparticles that recognize target molecules

Hoshino

Lee

Miura

2014

Polym J

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This article provides a brief review of the literature on the interaction between synthetic particles and biomacromolecules. Understanding the nonspecific interactions between biomacromolecules and synthetic particles is of great importance for using materials in vitro and in vivo. The interaction between functionalized polymer particles and proteins has been studied extensively to identify the main factor that governs the interaction in vitro. Recently, the composition and properties of the protein corona that forms on the surface of nanoparticles (NPs) in biofluids have been studied in the context of the function and distribution of the particles in vivo. In the meantime, NPs that recognize specific biomacromolecules have also been designed by tuning the combination and distribution of functional groups on gold NPs and dendrimers. It has also been shown that nano-gel particles that recognize target molecules can be achieved by (A) optimizing the combination and amount of functional groups in the particles and (B) molecular imprinting polymerization, in combination with (C) affinity purification. Some of these particles are capable of recognizing target molecules and neutralizing their function, even in the bloodstream of living animals, as 'plastic antibodies.'

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Synthetic Uniform Polymers and Their Use for Understanding Fundamental Problems in Polymer Chemistry

Cited by 26 publications

References 127 publications

Homogeneous Oligomeric Ligands Prepared via Radical Polymerization that Recognize and Neutralize a Target Peptide

Homogeneous Oligomeric Ligands Prepared via Radical Polymerization that Recognize and Neutralize a Target Peptide

Challenges for Natural Monomers and Polymers: Novel Design Strategies and Engineering to Develop Advanced Polymers

Interaction between synthetic particles and biomacromolecules: fundamental study of nonspecific interaction and design of nanoparticles that recognize target molecules

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