Synthetic polymer-derived single-network inks/bioinks for extrusion-based 3D printing towards bioapplications

Kumar, Sonu

doi:10.1039/d1ma00525a

Cited by 12 publications

(7 citation statements)

References 117 publications

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“…Synthetic polymers are produced by chemical reactions with tunable chemical structures and physical characteristics. The most common synthetic polymers used in 3D bioprinting are polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), polycaprolactone (PCL), poly lactic- co -glycolic acid (PLGA), and poly( l -lactic) acid (PLA). , These polymers cannot hold bioactive ingredients directly for bioprinting since they need organic solvents, heat, and toxic activators that may damage cells and bioactive components during the printing process. Moreover, they usually need further modifications to be functionalized to create cellular recognition and biological cues similar to the native ECM for cell proliferation and differentiation. , Some of the synthetic polymers applied as bioinks in previous studies are summarized in Figure and Table .…”

Section: Bioprinting For Cell Transplantationmentioning

confidence: 99%

Cell Encapsulation and 3D Bioprinting for Therapeutic Cell Transplantation

Samadi¹,

Moammeri

Pourmadadi

et al. 2023

ACS Biomater. Sci. Eng.

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The promise of cell therapy has been augmented by introducing biomaterials, where intricate scaffold shapes are fabricated to accommodate the cells within. In this review, we first discuss cell encapsulation and the promising potential of biomaterials to overcome challenges associated with cell therapy, particularly cellular function and longevity. More specifically, cell therapies in the context of autoimmune disorders, neurodegenerative diseases, and cancer are reviewed from the perspectives of preclinical findings as well as available clinical data. Next, techniques to fabricate cellbiomaterials constructs, focusing on emerging 3D bioprinting technologies, will be reviewed. 3D bioprinting is an advancing field that enables fabricating complex, interconnected, and consistent cell-based constructs capable of scaling up highly reproducible cell-biomaterials platforms with high precision. It is expected that 3D bioprinting devices will expand and become more precise, scalable, and appropriate for clinical manufacturing. Rather than one printer fits all, seeing more application-specific printer types, such as a bioprinter for bone tissue fabrication, which would be different from a bioprinter for skin tissue fabrication, is anticipated in the future.

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Section: Bioprinting For Cell Transplantationmentioning

confidence: 99%

Cell Encapsulation and 3D Bioprinting for Therapeutic Cell Transplantation

Samadi¹,

Moammeri

Pourmadadi

et al. 2023

ACS Biomater. Sci. Eng.

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“…For multipurpose 3D printing, renewed focus has been directed towards broadening the available materials libraries, an essential step for tackling the limitations posed by natural biopolymer feedstocks [21] with work on synthetic hydrogels as alternative 3D printing platforms. [22][23][24][25][26] The potential advantages of these systems include synthetic customizability, modular mechanical properties, and scalability. To address these current limitations, polypeptidebased hydrogels [27] allow for wide functionalization and customization through N-carboxyanhydride (NCA) monomers derived from readily available amino acid starting materials.…”

Section: Introductionmentioning

confidence: 99%

Design of Statistical Copolypeptides as Multipurpose Hydrogel Resins in 3D Printing

Murphy,

Delaney,

Kolagatla

et al. 2023

Adv Funct Materials

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Hydrogels possess desirable properties for the additive manufacturing of 3D objects, but a significant challenge is to expand the range of hydrogel feedstocks with defined molecular structure and functionality while retaining mechanical properties. To this end, the design of photopolymerizable copolypeptides, derived from linear or star‐shaped architectures which can be tailored to provide control over mechanical properties and associated 3D printing performance, are reported. Based on hydroxy ethyl‐L‐glutamine and vinylbenzyl‐L‐cysteine residues, physical crosslinking via β‐motif assembly is shown to afford hydrogels with viscoelastic properties that allow their use as resins for direct ink writing (DIW) and/or direct laser writing (DLW). The strategic incorporation of vinyl benzyl units permits rapid photocrosslinking of the self‐assembled hydrogels leading to mechanically robust 3D objects. Significantly, copolypeptide architecture directly influences hydrogel resin viscosity, which affords materials with tailorable characteristics for different 3D printing techniques, highlighting the intrinsic versatility of these systems.

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“…Along with the ever-growing diffusion of PHAs, processing technologies have also been studied and discussed, and reports on PHA scaffold fabrication predominantly rely on traditional fabrication techniques such as solvent casting, salt leaching, or thermally induced phase separation (TIPS), which offer no control over final geometry or stress formation during the drying process, limited design freedom, no possibility of customization, and three-dimensional development . However, these limitations can be easily overcome by additive manufacturing (AM) techniques, which have found incredible success in various fields of application, including biomedical ones, due to the high degree of design freedom and the extraordinary level of customization of the final geometries − that can even meet the architectural requirements of the defect site in patients . Many different AM approaches have been developed so far, but for polymer-based materials, extrusion-based technologies are the most widely applied and widely available.…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-Cellulose-Based Scaffolds for Biomedical Applications

Giubilini,

Messori,

Bondioli

et al. 2023

Biomacromolecules

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While biomaterials have become indispensable for a wide range of tissue repair strategies, second removal procedures oftentimes needed in the case of non-bio-based and nonbioresorbable scaffolds are associated with significant drawbacks not only for the patient, including the risk of infection, impaired healing, or tissue damage, but also for the healthcare system in terms of cost and resources. New biopolymers are increasingly being investigated in the field of tissue regeneration, but their widespread use is still hampered by limitations regarding mechanical, biological, and functional performance when compared to traditional materials. Therefore, a common strategy to tune and broaden the final properties of biopolymers is through the effect of different reinforcing agents. This research work focused on the fabrication and characterization of a bio-based and bioresorbable composite material obtained by compounding a poly(3hydroxybutyrate-co-3-hydroxyhexanoate) (PHBH) matrix with acetylated cellulose nanocrystals (CNCs). The developed biocomposite was further processed to obtain three-dimensional scaffolds by additive manufacturing (AM). The 3D printability of the PHBH−CNC biocomposites was demonstrated by realizing different scaffold geometries, and the results of in vitro cell viability studies provided a clear indication of the cytocompatibility of the biocomposites. Moreover, the CNC content proved to be an important parameter in tuning the different functional properties of the scaffolds. It was demonstrated that the water affinity, surface roughness, and in vitro degradability rate of biocomposites increase with increasing CNC content. Therefore, this tailoring effect of CNC can expand the potential field of use of the PHBH biopolymer, making it an attractive candidate for a variety of tissue engineering applications.

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Synthetic polymer-derived single-network inks/bioinks for extrusion-based 3D printing towards bioapplications

Abstract: Three dimensional (3D) printing, also known as additive manufacturing technique has revolutionarized the field of manufacturing with a great impact as compared to the other traditional methods. This technique has...

Cited by 12 publications

References 117 publications

Cell Encapsulation and 3D Bioprinting for Therapeutic Cell Transplantation

Cell Encapsulation and 3D Bioprinting for Therapeutic Cell Transplantation

Design of Statistical Copolypeptides as Multipurpose Hydrogel Resins in 3D Printing

3D-Printed Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-Cellulose-Based Scaffolds for Biomedical Applications

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