Synthetic Activities of Cultured Retinal Pigment Epithelial Cells From a Patient With Retinitis Pigmentosa

<i>rd1 </i>Mouse Retina Shows Imbalance in Cellular Distribution and Levels of TIMP-1/MMP-9, TIMP-2/MMP-2 and Sulfated Glycosaminoglycans

“…Earlier it has been reported that the increased biosynthesis of GAG in the RPE during retinitis pigmentosa deteriorates photoreceptor function, increases phagocytic activity and reduces the density of the RPE [42,43] . A number of serine proteinases activate MMP-1, MMP-10 and MMP-9 which degrade collagen type I or basement membrane matrices in the human capillary tubular network, and such a degradation of the ECM or destruction of the angiogenic scaffold leads to collapse of the angiogenic network [44] .…”

<i>rd1 </i>Mouse Retina Shows Imbalance in Cellular Distribution and Levels of TIMP-1/MMP-9, TIMP-2/MMP-2 and Sulfated Glycosaminoglycans

“…Earlier it has been reported that the increased biosynthesis of GAG in the RPE during retinitis pigmentosa deteriorates photoreceptor function, increases phagocytic activity and reduces the density of the RPE [42,43] . A number of serine proteinases activate MMP-1, MMP-10 and MMP-9 which degrade collagen type I or basement membrane matrices in the human capillary tubular network, and such a degradation of the ECM or destruction of the angiogenic scaffold leads to collapse of the angiogenic network [44] .…”

Retinal Pigment Epithelium Differentiation of Stem Cells: Current Status and Challenges

“…28 There is also evidence for alterations in the deposition of cell surface proteoglycans from RPE in the retinitis pigmentosa pathological condition. 29,30 Retinitis pigmentosa is also associated with progressive apoptosis of photoreceptors. 31 Transcription factors, proteins involved in retinal metabolism, splicing factors, and intracellular proteins have also been implicated in the onset of retinitis pigmentosa pathogenesis.…”

<i>rd1 </i>Mouse Retina Shows Imbalance in Cellular Distribution and Levels of TIMP-1/MMP-9, TIMP-2/MMP-2 and Sulfated Glycosaminoglycans

“…Earlier it has been reported that the increased biosynthesis of GAG in the RPE during retinitis pigmentosa deteriorates photoreceptor function, increases phagocytic activity and reduces the density of the RPE [42,43] . A number of serine proteinases activate MMP-1, MMP-10 and MMP-9 which degrade collagen type I or basement membrane matrices in the human capillary tubular network, and such a degradation of the ECM or destruction of the angiogenic scaffold leads to collapse of the angiogenic network [44] .…”

Retinal Pigment Epithelium Differentiation of Stem Cells: Current Status and Challenges

“…28 There is also evidence for alterations in the deposition of cell surface proteoglycans from RPE in the retinitis pigmentosa pathological condition. 29,30 Retinitis pigmentosa is also associated with progressive apoptosis of photoreceptors. 31 Transcription factors, proteins involved in retinal metabolism, splicing factors, and intracellular proteins have also been implicated in the onset of retinitis pigmentosa pathogenesis.…”

<i>rd1 </i>Mouse Retina Shows Imbalance in Cellular Distribution and Levels of TIMP-1/MMP-9, TIMP-2/MMP-2 and Sulfated Glycosaminoglycans

“…Earlier it has been reported that the increased biosynthesis of GAG in the RPE during retinitis pigmentosa deteriorates photoreceptor function, increases phagocytic activity and reduces the density of the RPE [42,43] . A number of serine proteinases activate MMP-1, MMP-10 and MMP-9 which degrade collagen type I or basement membrane matrices in the human capillary tubular network, and such a degradation of the ECM or destruction of the angiogenic scaffold leads to collapse of the angiogenic network [44] .…”

Retinal Pigment Epithelium Differentiation of Stem Cells: Current Status and Challenges

“…28 There is also evidence for alterations in the deposition of cell surface proteoglycans from RPE in the retinitis pigmentosa pathological condition. 29,30 Retinitis pigmentosa is also associated with progressive apoptosis of photoreceptors. 31 Transcription factors, proteins involved in retinal metabolism, splicing factors, and intracellular proteins have also been implicated in the onset of retinitis pigmentosa pathogenesis.…”