Synthesis, structure and in vitro antibacterial activities of new hybrid disinfectants quaternary ammonium compounds: Pyridinium and quinolinium stilbene benzenesulfonates

<i>In Vitro</i> Evaluation of the Biocompatibility of Newly Synthesized Bis-Quaternary Ammonium Compounds with Spacer Structures Derived from Pentaerythritol or Hydroquinone

“…As shown in Tables 3 and 4, some of the newly synthesized bis-QACs showed potent bacteriostatic activity against all tested microorganisms in comparison with that of BAC. In general, mono-QACs such as BAC are less effective against gram-negative bacteria; in contrast, bis-QACs have shown a wide antimicrobial spectra and a potent bacteriostatic activity against gram-negative and gram-positive bacteria, as reported earlier Okazaki et al, 1997;Maeda et al, 1998;Kourai et al, 1998;Maeda et al, 1999;Kourai et al, 2006;Chanawanno et al, 2010 . The antimicrobial properties of the bis-QACs that we synthesized also corresponded to the tendency reported study, we mixed the antiseptics with microorganism suspensions in sterilized water, and evaluated the lowest concentration required for completely killing of a test microorganism at 1 10 6 CFU/mL. Moreover, we diluted the antiseptics with the cell culture medium free from FBS to reduce the influence of the medium on the antiseptics, and NHEK NB cells were exposed to the dilutions for 48 hours.…”

A straightforward route for covalently anchored pyridinium salt onto upper rim of c-methylcalix[4]resorcinarene with selective antibacterial activity against Gram-positive bacteria

“…They are used as solvents, catalysts, and reagents in a variety of organic transformations [6,7]. Moreover, pyridinium salts have been identified as potent cytotoxic agents and have been used extensively in the dental profession for the treatment of oral infections [8][9][10][11]. However, high cost, tedious purification procedure of the product, as well as moisture sensitivity and decomposition of some pyridinium salts under normal atmospheric conditions, have restricted their widespread practical application on the industrial scale.…”

6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity

“…17 A potent antimicrobial activity has also been observed for some quinoline derivatives. 18 Even though the mechanism of the surfactant's antimicrobial activity is not known in deep detail, it seems that molecules carrying strong hydrophilic and hydrophobic functionality can change the physicochemical properties of cellular membranes, 19 and as a result of altered membrane permeability eventually cytolysis occurs.…”