Synthesis, structural characterization, in vitro comparative DNA/RNA binding, and computational studies of half-sandwich Ru (II)(ƞ6-p-cymene) aminoquinoline complex

Synthesis, structural insights, and biological screening of DNA targeted Ru(ii)(η6-p-cymene) complexes containing bioactive amino-benzothiazole ligand scaffolds

“…Furthermore, the Ru(arene) scaffold complexes that are weakly cytotoxic against tumor cells exhibit reduced toxicity or no toxicity towards (healthy) normal cells. 62,63…”

“…Furthermore, the Ru(arene) scaffold complexes that are weakly cytotoxic against tumor cells exhibit reduced toxicity or no toxicity towards (healthy) normal cells. 62,63 Both the Ru-based drug candidates 1 and 2 were tested for their cytotoxicity on lymphocytes where 2 appeared to be slightly more toxic as compared to 1. There was an insignificant difference between the viability of cells at lower concentrations, 20 and 40 mg ml À1 used, which was comparable to the control group or the TCBZ treated lymphocytes, particularly in the case of complex 1 treated cells.…”

Ru(II)(ƞ6-p-cymene) Conjugates Loaded onto Graphene Oxide: An Effective pH-Responsive Anticancer Drug Delivery System

“…Their binding affinity was determined by intrinsic binding constant K b and K sv values. Upon increase in the ct-DNA concentration, an increase in absorption intensity ‘hyperchromism’ with a slight red shift (3 and 4 nm) was observed [ 32 ]. These results indicated that nanocomposites interacted with ct-DNA via electrostatic or groove binding modes due to the presence of two labile chloride and nitrogen atoms in the heterocyclic benzothiazole ring anchored to the ruthenium center.…”