Synthesis, spectroscopic studies and crystal structure of the Schiff base ligand L derived from condensation of 2-thiophenecarboxaldehyde and 3,3′-diaminobenzidine and its complexes with Co(II), Ni(II), Cu(II), Cd(II) and Hg(II): Comparative DNA binding studies of L and its Co(II), Ni(II) and Cu(II) complexes

Shakir, Mohammad; Abbasi, Ambreen; Azam, Mohammad; Khan, Asad U.

doi:10.1016/j.saa.2011.05.077

Cited by 60 publications

(15 citation statements)

References 47 publications

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“…The magnetic moment value of the Co(II) complexes is in the range 4.6 5.05. 05 B.M., confirming the high-spin octahedral configuration [33,34].…”

Section: Cobalt(ii) Complexesmentioning

confidence: 71%

“…The electronic spectra of Co(II) complexes (2-4) show a broadband in the range 520-510 nm corresponding to 4 T 1g (F)→ 4 A 2g (F) transition. It may be concluded that the complexes show octahedral geometry [33]. The magnetic moment value of the Co(II) complexes is in the range 4.6 5.05.…”

Section: Cobalt(ii) Complexesmentioning

confidence: 87%

“…The magnetic moment of all the Cu(II) complexes is in the range of 2.12 -1. 8 B.M., these values correspond to one unpaired electron[33].…”

mentioning

confidence: 99%

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Novel (N4) Macrocyclic Metal Complexes: Synthesis, Characterization, Spectral Studies and Anticancer Activity

El‐Boraey¹,

EL-Gammal²

2018

CHEM

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Introduction:A new series of mononuclear Fe(II), Co(II), Ni(II), Cu(II) and Pd(II) complexes correspond to tetradentate macrocyclic nitrogen ligandi.e.naphthyl-3,4:10,11-dibenzo,7-methylene,8-methyl,6-phenyl-1,5,9,13-tetraazacyclohexadecane-5,8-diene-2,12-dione metal(II) complexes, have been synthesized by the template condensation reaction.Methods:The complexes have been characterized by elemental analysis, spectral (IR, UV–Vis, and ESR, molar conductivity, and magnetic as well as thermal analysis measurements.Results:On the basis of above studies, an octahedral geometry has been proposed for all complexes except Cu(II) nitrate complex that adopt square pyramidal geometry, and square planar geometry for Pd(II) chloride complex, respectively.Conclusion:The thermal behavior and the kinetic parameters of degradation were determined using Coats-Redfern and Horowitz-Metzger methods. Moreover, thein vitroantitumor activity of the some synthesized complexes against human breast and human hepatocarcinoma cell lines (MCF-7) and (HePG2), respectively has been studied.

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“…The magnetic moment value of the Co(II) complexes is in the range 4.6 5.05. 05 B.M., confirming the high-spin octahedral configuration [33,34].…”

Section: Cobalt(ii) Complexesmentioning

confidence: 71%

Section: Cobalt(ii) Complexesmentioning

confidence: 87%

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Novel (N4) Macrocyclic Metal Complexes: Synthesis, Characterization, Spectral Studies and Anticancer Activity

El‐Boraey¹,

EL-Gammal²

2018

CHEM

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“…Such shift in bands positions in the copper complexes supported the coordination of the azomethine nitrogen to the copper center. [ 25,33 ]…”

Section: Resultsmentioning

confidence: 99%

Synthesis, structure elucidation, DNA binding and molecular docking studies of novel copper(II) complexes of two 1,3,4‐thiadiazolethiosemicarbazone derivatives

Takroni

Farghaly

Harras

et al. 2020

Applied Organom Chemis

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Four novel Cu(II) chelates were synthesized by reacting hydrated CuCl2 and Cu(CH3COO)2 with two derivatives of 1,3,4‐thiadiazolethiosemicarbazone. The structures and geometries of the synthesized complexes were deduced applying the alternative analytical and spectral tools confirming the complexes to have the formulae [(LH)Cu(Cl)]•0.5H2O, [(LH)Cu(OAc)(H2O)2]•0.5H2O, [(LCl)Cu(Cl)(H2O)2]•H2O and [(LCl)Cu(OAc)]; where LH and LCl are phenyl and p‐chlorophenyl derivatives of 1,3,4‐thiadiazolethiosemicarbazone ligands, respectively (deprotonated form). IR spectral data confirmed the coordination of the ligands to the copper center as monobasic tridentate in the thiol form. Thermal analysis, UV–Vis spectra and magnetic moment assured the geometry around the copper center to be square planar, trigonal bipyramid and octahedral which have been confirmed by the computational studies. The two ligand derivatives and their copper complexes were applied to evaluate their binding modes with SS‐DNA via UV–Vis spectral titration and viscosity measurements. The DNA‐binding constant (kb) values of the investigated derivatives were calculated and compared with ethidium bromide in order to assess their mode of binding with DNA. Moreover, docking study of these complexes was carried out to recognize the drug–DNA interactions and to calculate their binding energies.

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“…The absorption maxima and magnetic moment values are depicted in Table 3. The electronic spectra of the free ligand (HL) displayed two bands at 258 nm (38 760 cm -1 ) and 319 nm (31 348 cm -1 ) are intra ligand charge transfer, which indicates π→π* and n→π* transitions for phenyl ring and the azomethine chromophore, respectively [27] . The bands in the complexes (1-5) were shifted to a higher wavelength, which might be attributed to the donation of a lone pair electron in a sp 2 -hybridized orbital of the imino nitrogen atom of the ligand (HL) to the metal.…”

Section: Electronic Absorption Spectral Titrationmentioning

confidence: 99%

Antimicrobial, Antioxidant and DNA Interaction Studies of Water-soluble Complexes of Schiff Base Bearing Morpholine Moiety

Sakthikumar¹,

Raja²,

Sankarganesh³

et al. 2018

pharmaceutical-sciences

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Cited by 60 publications

References 47 publications

Novel (N4) Macrocyclic Metal Complexes: Synthesis, Characterization, Spectral Studies and Anticancer Activity

Novel (N4) Macrocyclic Metal Complexes: Synthesis, Characterization, Spectral Studies and Anticancer Activity

Synthesis, structure elucidation, DNA binding and molecular docking studies of novel copper(II) complexes of two 1,3,4‐thiadiazolethiosemicarbazone derivatives

Antimicrobial, Antioxidant and DNA Interaction Studies of Water-soluble Complexes of Schiff Base Bearing Morpholine Moiety

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