Synthesis, spectroscopic characterization and antibacterial screening of novel Mannich bases of Ganciclovir

Joshi, Sheela; Bilgaiyan, Purti; Pathak, Anju

doi:10.1016/j.arabjc.2013.02.013

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…The synthesized Mannich Bases appear to be better and more potent antibacterial agents than sulphonamides themselves. These results warrant detailed pharmacological studies of these Mannich Bases [7]. Mannich Bases are not only important in research, but they also have considerable practical use in a wide range of other fields.…”

Section: Innovation Of New Drugs Via Mannich Reactionmentioning

confidence: 81%

Synthesis of New Antibiotics via Mannish Reaction

Bilgaiyan

2018

PPS

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Section: Innovation Of New Drugs Via Mannich Reactionmentioning

confidence: 81%

Synthesis of New Antibiotics via Mannish Reaction

Bilgaiyan

2018

PPS

Self Cite

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“…Natural ingredients have been utilised for a very long time to create medicines that are used to cure human illnesses. According to Joshi S. et al [1], many modern medications are enhanced versions of traditional ones that have been altered to make patients feel better. As a result of multiple reactions, a range of therapeutic agents produce superior outcomes and have symbolic properties that can lead to the synthesis of new chemical entities.…”

Section: Introductionmentioning

confidence: 99%

The Versatility of Mannich Reaction: An Overview

Bilgaiyan,

Modi,

Shivhare

2023

J. Phys.: Conf. Ser.

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- One of the most significant processes for creating carbon-carbon bonds in organic synthesis is the Mannich reaction. It offers amino carbonyl compounds, crucial synthetic building blocks for many medicines. This Mannich bases are made by combining primary and/or secondary amines, formaldehyde, and active hydrogen molecules. Among those that are active hydrogen compounds include an acid, phenol, ketone, amide, etc. contribution involved the synthesis of 3,5 dimethyl carboxamide using a number of biologically active sulphonamides, which was followed by analysis of elements and spectrum analyses techniques using, IR, UV and 1HNMR. Escherichia coli, Staphylococcus aureus, and Bacillus subtilis were among the pathogenic microorganisms tested for the compounds’ antibacterial efficacy at different doses. We examined the bactericidal effectiveness of parent sulphonamides and derived Mannish bases. To establish whether synthetic Mannish bases were dangerous, the LD50 test was utilised.

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“…Mannich bases received enormous appreciation for their immense realm of applications and many studies have focussed on structural modifications of the Mannich bases and on the vast variety of their biological activities [9,10]. A number of synthetic modifications, such as heterocyclic infused [11,12], thiophene based [13], aurone based mannich bases [14], lawsone based mannich bases [15], berberine based mannich bases [16],or other substitutions [17][18][19][20], have also been reported to affect the biological activities including anticancer activities [21,22] of these bases.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Novel 5-Oxo-1-Phenylpyrrolidine-3-Carboxylic Acid Analogs

et al. 2018

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A number of 5-oxo-1-phenyl-4-(substituted methyl) pyrrolidine-3-carboxylic acid derivatives bearing pyrrolidine ring and methylamino residues in their structure were synthesized as potential antibacterial drugs. The chemical structures of all the compounds were established by their UV-Vis absorption spectroscopy, IR, H,C NMR and mass spectroscopy. The in vitro antibacterial screening of all novel compounds was done against gram-positive Staphylococcus aureus, Bacillus subtilis and gram-negative Pseudomonas aeruginosa. The results revealed that compounds 5d, e, f and g showed moderate to good activity against the tested microbes.

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Synthesis, spectroscopic characterization and antibacterial screening of novel Mannich bases of Ganciclovir

Cited by 8 publications

References 15 publications

Synthesis of New Antibiotics via Mannish Reaction

Synthesis of New Antibiotics via Mannish Reaction

The Versatility of Mannich Reaction: An Overview

Synthesis and Biological Evaluation of Novel 5-Oxo-1-Phenylpyrrolidine-3-Carboxylic Acid Analogs

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