Synthesis, Spectroscopic and Anti-Microbial Assessment of Metal (II) Complexes of Schiff Base Ligand Derived from 4-(Tert Butyl)-O-Phenylenediamine, 5-Nitro Salicylaldehyde and 5-Chloro-2-Hydroxy Acetophenone.

Abstract

In this study, the metal complexes of Schiff base ligand were synthesized using Nickel (II) acetate tetrahydrate, Zinc (II) acetate dihydrate, and Cadmium (II) acetate dihydrate, in reacting with 4-tertbutyl-o-phenylenediamine, 5-nitro salicylaldehyde, and 5-chloro-2-hydroxyacetophenone, respectively. The UV-Vis, Fourier transform infrared and ESI-Mass spectrometric characterizations enabled the analysis of the synthesized metal complexes. Molar conductivity investigations indicate all complexes are diamagnetic and non-electrolyte in nature. In pursuance of evaluating the chelation effects of metal ions, the Schiff bases and their Nickel, Zinc, and Cadmium complexes have been tested for their antibacterial activities on a variety of pathogens such as E. coli, Klebsiella pneumonia, Bacillus subtilis, and Staphylococcus aureus. Additionally, the zone of inhibition method was utilized to test the antifungal activity of the Schiff bases using two different pathogens such as Candida albicans and Aspergillus Niger.