Synthesis, spectral characterization and biological evaluation of novel 1-(2-(4,5-dimethyl-2-phenyl-1H-imidazol-1-yl)ethyl)piperazine derivatives

Abstract

A simple, highly useful synthesis of 1-(2-(4,5-dimethyl-2-phenyl-1H-imidazol-1-yl)ethyl)piperazine derivatives is achieved by a four component cyclo condensation of diacetyl, aromatic aldehyde, 2-(piperazin-1-yl)ethanamine and ammonium acetate using SO 4 2À /Y 2 O 3 as a catalyst in ethanol. The synthesized compounds were characterized by IR, 1 H and 13 C NMR and mass spectral studies. All the synthesized compounds were screened for their in vitro antimicrobial studies. Among the newly synthesized compounds 5d, 5e, 5h and 5m showed excellent antibacterial and antifungal activities when compared to the standard drugs.ª 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University.

Catalytic Synthesis of 1,2,4,5‐Tetrasubstituted 1H‐Imidazole Derivatives: State of the Art

“…[112] In 2015, sulphated yttria (SO4 2-/Y2O3) was used by Krishnasamy and coworkers as a recyclable catalyst for the synthesis of 1-[2-(2,4,5-triphenyl-1H-imidazol-1-yl)ethyl]piperazine derivatives 40 in 83-93% yield by cyclo-condensation of benzil ( 5), aryl aldehydes 14, 1-N-(2-aminoethyl)piperazine (39) and AcONH4 in EtOH at 80 °C for 10 h (Scheme 29). [113] Scheme 29. Sulfated yttria-catalyzed synthesis of imidazoles 40…”

Synthesis, crystal structure investigation, DFT studies and DPPH radical scavenging activity of 1-(furan-2-ylmethyl)-2,4,5-triphenyl- 1H -imidazole derivatives

“…The synthesis of four components assembling of a mixture of benzil (mmol ), ammonium acetate (2 mmol), furfurylamine (mmol) and benzaldehyde (mmol) in distilled ethanol medium (20 ml) in the presence of sulphated yatria (SO 4 2-/Y 2 O 3 (50 mg) as a catalyst [33]. The reaction mixture was refluxed at the boiling point of ethanol (78ºC) and the completion of the reaction was monitored by thin layer chromatography (TLC) technique using benzene: ethyl acetate (9:1) as the eluent.…”

Synthesis, spectral characterization, single crystal X-ray diffraction and DFT studies of 4-((2,4,5-triphenyl-1H-imidazol-1-yl)methyl)pyridine derivatives

“…mg)[26] was stirred and refluxed at 80 ˚C in ethanol (20 mL) for 10 hrs. The progress of the reaction was monitored by TLC.…”