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Cited by 23 publications
(10 citation statements)
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References 23 publications
(10 reference statements)
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“…Although the biological profile of jasplakinolide is established, many mechanistic details are still missing in terms of molecular target identification. For this reason, the natural metabolite was synthetically modified with a β-amino acid in the cyclopeptide backbone, similar to the parent compound [99]. However, the extreme simplified polyketide moiety, which was necessary to allow more synthetic accessibility of analogs, was detrimental to biological activity [68].…”
Section: Compounds With Anti-tumor Activitymentioning
confidence: 99%
“…Although the biological profile of jasplakinolide is established, many mechanistic details are still missing in terms of molecular target identification. For this reason, the natural metabolite was synthetically modified with a β-amino acid in the cyclopeptide backbone, similar to the parent compound [99]. However, the extreme simplified polyketide moiety, which was necessary to allow more synthetic accessibility of analogs, was detrimental to biological activity [68].…”
Section: Compounds With Anti-tumor Activitymentioning
confidence: 99%
“…While 75 both toxins do not affect ATP hydrolysis, they strongly delay the release of Pi (Barden et al, 76 1987;Dancker and Hess, 1990;Vig et al, 2011), suggesting a close correlation between 77 filament stability and the presence of Pi. 78 Over the years tremendous effort was put into the design and synthesis of phalloidin and 79 JASP derivatives to enable specific labeling of actin filaments and to exploit their potential as 80 therapeutics in anticancer or antimalaria therapy (Anderl et al, 2012;Holzinger, 2009;81 Lukinavičius et al, 2014;Terracciano et al, 2005;E. Wulf et al, 1979;Yao et al, 2019).…”
Section: Introduction 34mentioning
confidence: 99%
“…Furthermore, syntheses of simplified jasplakinolide analogues have been reported. [11,12] Surprisingly, syntheses of chondramides were achieved only recently. The reason was that the configuration at the stereogenic centers was not given in the original article.…”
Section: Introductionmentioning
confidence: 99%