Synthesis, purification, and chemical characterization of 20‐dihydro‐6‐methylprednisone, an isomeric metabolite of methylprednisolone in the horse, for use as an analytical standard
Abstract:Synthesis, purification, and chemical characterization of 20-dihydro-6methylprednisone, an isomeric metabolite of methylprednisolone in the horse, for use as an analytical standardTo the Editor Methylprednisolone acetate, pregna-1,4-diene-3,20-dione, 21-(acetoxy)-11,17-dihydro-6-methyl-,(6α,11β)-, is a synthetic glucocorticoid pro-drug widely used in equine medicine. [1] It is recognized as a therapeutic medication by many equine organizations, including the American Association of Equine Practitioners (AAEP),… Show more
“…The limit of detection (LOD) was 0.025 ng/mL. This analytical method has been shown to exclude 20‐dihydro‐6‐methylprednisolone, an isomeric metabolite of methylprednisolone in the horse and a possible confounding isomeric metabolite of methylprednisolone with respect to the unequivocal identification and confirmation of methylprednisolone in post‐MP administration equine plasma samples .…”
Practitioners should be aware that injection of DTJ, CS and MFT joints, and combining MP acetate with HA may prolong its clearance, and withdrawal times for competition in regulated equine sports.
“…The limit of detection (LOD) was 0.025 ng/mL. This analytical method has been shown to exclude 20‐dihydro‐6‐methylprednisolone, an isomeric metabolite of methylprednisolone in the horse and a possible confounding isomeric metabolite of methylprednisolone with respect to the unequivocal identification and confirmation of methylprednisolone in post‐MP administration equine plasma samples .…”
Practitioners should be aware that injection of DTJ, CS and MFT joints, and combining MP acetate with HA may prolong its clearance, and withdrawal times for competition in regulated equine sports.
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