Synthesis, physicochemical properties, antimicrobial and antioxidant studies of pyrazoline derivatives bearing a pyridyl moiety

Lone, Imtiyaz H.; Khan, Khaliquz Zaman; Fozdar, Bharat Inder

doi:10.1007/s00044-013-0643-z

Cited by 22 publications

(17 citation statements)

References 22 publications

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“…The selected golden yellow crystal (0.350 x 0.300 x 0.250 mm 3 ) of the compound was mounted on a Bruker AXS KAPPA APEX-II diffractometer at 293 (2) K with a graphite monochromatic Mo-Kα radiation (k = 0.71073 Å). The corrections for LP factors and empirical absorption were applied to the data.…”

Section: Methodsmentioning

confidence: 99%

“…Easily tunable properties suit these electron rich nitrogen heterocycles to be used extensively as useful synthons in organic synthesis [1][2] as well as for medicinal applications [3][4]. These significant key motifs in heterocyclic chemistry are known not only from their pharmaceutical applications but also as materials showing excellent optical properties.…”

Section: Introductionmentioning

confidence: 99%

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Study on the Reactivity of Amino Acid Chemosensor, NPFNP, with Ethanol: Structural Elucidation through Single Crystal XRD and DFT Calculations

Varghese

Al‐Busafi

Suliman

et al. 2017

SQU Journal for Science

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ABSTRACT:A novel ethoxy derivative of an amino acid chemosensor, 3-naphthyl-1-phenyl-5-(2ʹ-fluoro-5ʹ-nitrophenyl)-2-pyrazoline (NPFNP), has been synthesized and characterized by different spectroscopic methods. A single crystal of the ethoxy derivative, 3-naphthyl-1-phenyl-5-(2ʹ-ethoxy-5ʹ-nitrophenyl)-2-pyrazoline NPENP, has been obtained and characterized. The structure holds interest as it carries biologically active pyrazoline as a central ring attaching to electron donating and withdrawing substituents. The major motivation for this work was to gain detailed insight into the structural parameters of this compound for investigating the influence of crystal packing and geometrical dimensions on optical properties. Time-dependent DFT calculations have been employed for comparing the XRD data with theoretical parameters. The results show that the DFT method at B3LYP/6-31G level can well reproduce the structure of the title compound.Keywords: Pyrazoline; UV absorption; Crystal structure; Chemosensor; TD-DFT. ‫األمينيه‬ ‫األحماض‬ ‫كاشف‬ ‫تفاعل‬ ‫دراسة‬

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Study on the Reactivity of Amino Acid Chemosensor, NPFNP, with Ethanol: Structural Elucidation through Single Crystal XRD and DFT Calculations

Varghese

Al‐Busafi

Suliman

et al. 2017

SQU Journal for Science

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“…With the antitrypanosomal activity of chalcone hybrids in mind [8e11], we were intrigued to determine whether pyridylchalcones would also be active against this target. It was anticipated that pyridyl analogues would exhibit the same low toxicity shown by compounds containing the chalcone nucleus but with improved bioavailability [14]. The introduction of a pyridine group will reduce the lipophilicity of the molecule and increase water solubility, both of which should ease formulation.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antitrypanosomal activities of novel pyridylchalcones

Bhambra

Ruparelia

Tan

et al. 2017

European Journal of Medicinal Chemistry

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a b s t r a c tA library of novel pyridylchalcones were synthesised and screened against Trypanosoma brucei rhodesiense. Eight were shown to have good activity with the most potent 8 having an IC 50 value of 0.29 mM.Cytotoxicity testing with human KB cells showed a good selectivity profile for this compound with a selectivity index of 47. Little activity was seen when the library was tested against Leishmania donovani. In conclusion, pyridylchalcones are promising leads in the development of novel compounds for the treatment of human African trypanosomiasis (HAT).

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“…The crucial role played by small heterocyclic molecules in drug design cannot be denied. These molecules act as highly functionalized scaffolds [7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, in Silico Physicochemical Properties and Biological Activities of Some Pyrazoline Derivatives

K²

2017

Asian J Pharm Clin Res

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Objectives: Nitrogen-containing heterocyclic compounds play an important role in medicinal chemistry. Among them, five-membered ring pyrazolines have found to possess many biological and pharmacological activities such as anticancer, antitubercular, antimicrobial, anti-inflammatory. Objective is to determine the physicochemical and drug-like properties of the synthesized pyrazolines by in silico methods and to screen their antidiabetic and antioxidant activities. Methods:Chalcones were synthesized from naphthaldehyde by condensing with various substituted acetophenones in ethanol and cyclized into pyrazolines using semicarbazides/thiosemicarbazides by conventional and microwave oven synthesis. The physicochemical and drug-like properties were determined using computational tools. Anti-diabetic activity was evaluated by alpha amylase inhibition assay method. Antioxidant activity studies were done by 2,2-diphenyl-1-picrylhydrazyl and nitric oxide method.Results: Pyrazolines were synthesized from chalcones. Microwave irradiated synthesis of chalcone was carried out to get higher yield with less reaction period as compared to conventional method. The synthesized pyrazolines produce yield around 68% (conventional) and 85% (microwave). In silico studies showed considerable values satisfying all the parameters of physicochemical and Lipinski's Rule of Five properties. Among the compounds tested for antidiabetic and antioxidant studies, some showed promising activity. Conclusion:Physiochemical and drug-like properties revealed that these compounds have good bioavailability and drug likeness properties. Hence, these compounds are found to be interesting lead molecules for further synthesis as antidiabetic and antioxidant agents.

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Synthesis, physicochemical properties, antimicrobial and antioxidant studies of pyrazoline derivatives bearing a pyridyl moiety

Cited by 22 publications

References 22 publications

Study on the Reactivity of Amino Acid Chemosensor, NPFNP, with Ethanol: Structural Elucidation through Single Crystal XRD and DFT Calculations

Study on the Reactivity of Amino Acid Chemosensor, NPFNP, with Ethanol: Structural Elucidation through Single Crystal XRD and DFT Calculations

Synthesis and antitrypanosomal activities of novel pyridylchalcones

Synthesis, in Silico Physicochemical Properties and Biological Activities of Some Pyrazoline Derivatives

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