Synthesis, phase stability of hydroxyapatite–silver composite with antimicrobial activity and cytocompatability

Synthesis, characterization, in vitro bioactivity and antimicrobial activity of magnesium and nickel doped silicate hydroxyapatite

“…Antibacterial properties of Ni 2 þ doped Mg-SiHA samples were investigated qualitatively and quantitatively against P. aeruginosa, and E.coli, respectively. Results showed that HA, SiHA, and Mg-SiHA had no effect on the growth of P. aeruginosa, and E.coli, which is consistent with previous studies conducted on different types of microorganism [60][61][62][63], however incorporation of Ni 2 þ played a vital role in increased activity of Mg-SiHA against microorganism.…”

Ceramics and ceramic coatings in orthopaedics

“…Additions of bone morphogenetic proteins and growth factors [568], mesenchymal stem cells [603], and therapeutic genes [604] have also been explored for similar reasons. Elutable silver [605,606] or antibiotics [607,608] have been incorporated to inhibit nosocomial infections. Composites of synthetic bio-erodible polymers [609] (e.g., polylactic acid, polyglycolic acid, and polylactic-co-glycolide), natural occurring polymers [610][611][612] (e.g., alginate, collagen, chitosan), or nonresorbing polyurethane [613] have been constructed principally to improve mechanical properties.…”

Effect of micron sized silver particles concentration on the adhesion induced by sintering and antibacterial properties of hydroxyapatite microcomposites

“…The incorporation of additional cations within its structure may induce an antibacterial effect, with positive results on the reduction of risks associated with post-implantation infections. Particular attention has been given to silver: in the soluble or ionic form it is considered a promising antibacterial agent, [1][2][3][4][5][6] its use within the HAP giving it antibacterial properties that vary proportionally with the incorporated silver concentration. Various silver incorporation methods have been used for adding antibacterial properties to HAP-based ceramic or composites.…”

“…[2,4,13,14] This method allows a careful control of nanoparticles shape and size, which influence the antibacterial effect of the obtained material. [15] However, this solution is regarded with precaution as the effects of silver nanoparticles on the human body and the environment is not fully clarified yet.…”

“…[3,4,[6][7][8][9] Since, very commonly, the doping agent substitutes different elements from the crystal lattice of the ceramic, an alternative term used for these materials is 'silver-substituted hydroxyapatite' . The addition of silver as particles allows defining these materials as 'hydroxyapatite -silver composites' , [2,[10][11][12] However, the different interactions between the two phases may require a deeper level of classification.…”