Synthesis of well-defined catechol polymers for surface functionalization of magnetic nanoparticles

Abstract

Well-defined fluorescent functional polymers with terminal catechol groups were synthesized by SET-LRP under aqueous conditions for “grafting to” modification of iron oxide nanoparticles.

The effect of linker length on ConA and DC-SIGN binding of S-glucosyl functionalized poly(2-oxazoline)s

“…34 As depicted in Scheme 1, the thiol groups of Ac 4 Glc-SH were reacted with the double bonds of 2-isopropenyl-2-oxazoline (iPOx) in the presence of solid-phase butyl amine resin as a catalyst in dry acetonitrile using a 365 nm UV lamp overnight. The thiol-ene click reaction was monitored and quantitative conversions were confirmed by 1 H-NMR, 13 C-NMR and ESI-MS. As seen in 1 H and 13 C NMR in Fig. 1, the glycomonomer structure was confirmed by the disappearance of the vinyl peaks at 5.5 and 5.7 ppm of iPOx, the appearance of new peaks at 2.6-2.8 and 3.0-3.1 ppm, and also the chemical shift of the -CH 3 protons of iPOx after the reaction due to difference in chemical environment indicating the formation of the corresponding thioether structure.…”

“…Glycopolymers (GPs) that are essentially synthetic carbohydrate containing macromolecules can display similar structural and functional features to oligosaccharides such as variations in anomeric status, linkage positions, branching, and introduction of site specific substitutions. [9][10][11][12][13][14] Therefore, even though there have been great developments in the synthesis of welldefined glyco-polymers over the last decade, it is still challenging to provide precision on the control of chain lengths, monomer repeat sequences, compositions, and architectures. 15,16 Furthermore, in order to promote the development of glyconanoparticles for different bio-related applications such as drug delivery, biomaterials, and biotechnologies it is necessary to understand the basis of selectivity and strength in the specific interactions between glycomaterials and lectins in more detail.…”

“…H-NMR (left) and13 C-NMR (right) spectra of the Ac 4 Glc-S-Ox monomer. Schematic representation of the synthesis of one-pot glycomonomer approach (top) and copolymerization of 2-alkenyl-2-oxazolines with 2-ethyl-2-oxazoline at various ratios and followed by the glycosylation reaction (bottom).…”

Phenolische Bausteine für die Assemblierung von Funktionsmaterialien

“…Frühe synthetische phenolische Polymere basierten auf der Reaktion zwischen kommerziell erhältlichen Polymeren und DOPA, und seitdem hat sich das Gebiet zu synthetischen Polymeren mit Catecholen und Gallolen entwickelt. Synthetische phenolische Polymere wurden auf verschiedenen Wegen hergestellt, unter anderem durch funktionelle Initiatoren, Modifizierung nach der Polymerisation und Einbau in die Polymerhauptkette, wobei der letztere Ansatz der Schwerpunkt dieses Abschnitts ist. Andere nützliche Synthesetechniken werden ebenfalls kurz erwähnt.…”

Significant Performance Enhancement of Polymer Resins by Bioinspired Dynamic Bonding

“…[33,34] As anticipated, the curing of the PMA resin was not completed in the given period of time, <1–5 min, which is not acceptable for practical dental applications.…”