“…There is an urgent need for new therapeutics that are more effective and less toxic than conventional treatments used to treat infectious diseases, including leishmaniasis [ 25 ]. Thiophenes derivatives are known for their therapeutic applications and have shown promising results to treat different types of cancer, degenerative diseases, HIV, and malaria [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Thus, we evaluated the anti-leishmania activity and selectivity of nine thiophene derivatives against L. major , and potential MOA was elucidated for our best candidate, 5D .…”