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Cited by 65 publications
(17 citation statements)
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References 50 publications
(39 reference statements)
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“…There is an urgent need for new therapeutics that are more effective and less toxic than conventional treatments used to treat infectious diseases, including leishmaniasis [ 25 ]. Thiophenes derivatives are known for their therapeutic applications and have shown promising results to treat different types of cancer, degenerative diseases, HIV, and malaria [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Thus, we evaluated the anti-leishmania activity and selectivity of nine thiophene derivatives against L. major , and potential MOA was elucidated for our best candidate, 5D .…”
Section: Discussionmentioning
confidence: 99%
“…There is an urgent need for new therapeutics that are more effective and less toxic than conventional treatments used to treat infectious diseases, including leishmaniasis [ 25 ]. Thiophenes derivatives are known for their therapeutic applications and have shown promising results to treat different types of cancer, degenerative diseases, HIV, and malaria [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Thus, we evaluated the anti-leishmania activity and selectivity of nine thiophene derivatives against L. major , and potential MOA was elucidated for our best candidate, 5D .…”
Section: Discussionmentioning
confidence: 99%
“…The tumor volume (expressed in mL) was measured every three days using the plethysmometer apparatus until the 15th day, when the animals were sacrificed. The variation in volume was determined by the difference between the volume measured on the day and the basal volume, and then the variation in tumor volume was calculated according to the following formula [ 49 ]: …”
Section: Methodsmentioning
confidence: 99%
“…Thiosemicarbazones and their complexes are well known for their pharmacological properties, as antimicrobial (Plech et al, 2011;Pandeya et al, 1999;Kü çü kgü zel et al, 2006), antiinflammatory (Palaska et al, 2002) and antiumoural (de Oliveira et al, 2015) agents. Complexes of thiosemicarbazones are studied in the literature as drug candidates, biomarkers and biocatalysts (Hayne et al, 2014;Lim et al, 2010).…”
Section: Chemical Contextmentioning
confidence: 99%