Synthesis of some novel 2,5-disubstituted thiazolidinones from a long chain fatty acid as possible anti-inflammatory, analgesic and hydrogen peroxide scavenging agents

Kumar, Vipin; Sharma, Archana; Sharma, Prabodh Chander

doi:10.3109/14756366.2010.489897

Cited by 26 publications

(13 citation statements)

References 28 publications

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“…The content was put undisturbed for 24h. The solid thus obtained was separated by filtration and recrystallized from Methanol to give the Corresponding Schiff bases (a-k) (Kumar et al, 2011;Kumar et al, 2018).…”

Section: Synthesis Of Schiff Basesmentioning

confidence: 99%

Synthesis, characterization and antimicrobial evaluation of novel azole based (Benzoic Acid) derivatives

Shrivastava¹,

Sharma²,

Sharma³

et al. 2019

Asian J Pharm Pharmacol

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The aim of present study was the Synthesis and characterization of Azoles Based Benzoic Acid Derivative. Materials and Methods: The compounds were prepared by reaction of Benzoic Acid with thiosemicarbazide in the presence of Phosphorus oxychloride to yield 1, 3, 4-thiadiazole nucleus. Further this thiadiazole was treated with different aromatic aldehydes in presence of methanol to yield corresponding Schiff's bases. All the Schiff's bases thus obtained were reacted with Thioglycolic acid to yield the title compounds. Synthesized derivatives were characterized by IR, H NMR and screened for their antibacterial () and antifungal 1 S. aureus, B. subtilis, E. coli, and P. aerugiosa activity (A. Niger and C. albicans). The experimental data of present research work reveals Results and conclusion: that the synthesized azole derivative (1, 2, 9, and 11) demonstrates significant Antibacterial and Antifungal Activity as shown in table no. 1and out of all synthesized compounds the halogen substituted thiazolidinones derivatives are found most active.

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Section: Synthesis Of Schiff Basesmentioning

confidence: 99%

Synthesis, characterization and antimicrobial evaluation of novel azole based (Benzoic Acid) derivatives

Shrivastava¹,

Sharma²,

Sharma³

et al. 2019

Asian J Pharm Pharmacol

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“…One of the main objectives of organic and medicinal chemistry is the design, synthesis, and production of molecules having a value as human therapeutic agents (Kumar et al, 2011b). In the recent past, 4-thiazolidinone scaffold and its derivatives have attracted considerable attention of medicinal chemists and have become an important class of heterocyclic compounds because of their diverse biological activities such as anti-inflammatory (Kumar and Rajput, 2009;Ottana et al, 2005;Geronikaki et al, 2008), analgesic (Tandon et al, 1985;Knutsen et al, 2007) antimycobacterial (Kucukguzel et al, 2002;Srivastav et al, 2005), antimicrobial (Ozkirimli et al, 2009;Bondock et al, 2007;Madhukar et al, 2009;Fuloria et al, 2009), antiarrhythmic (Amr et al, 2009), anti-HIV activity (Kucukguzel et al, 2006;Barreca et al, 2001), and anticonvulsant (Shiradkar et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 2-(aryl)-5-(arylidene)-4-thiazolidinone derivatives with potential analgesic and anti-inflammatory activity

et al. 2011

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A series of novel N-[5-(arylidene)-2-(aryl)-4-oxo-thiazolidin-3-yl]-4-biphenylcarboxamide derivatives was synthesized and evaluated for analgesic and anti-inflammatory activity. In this study, biphenyl-4-carboxylic acid hydrazide was converted to the corresponding aryl hydrazones using aryl aldehydes in the presence of catalytic amount of glacial acetic acid. The aryl hydrazones on reaction with thioglycolic acid in the presence of anhydrous zinc chloride yielded N-[2-(aryl)-4-oxo-thiazolidin-3-yl]-4-biphenylcarboxamide which further on reaction with aromatic aldehydes in the presence of anhydrous sodium acetate and glacial acetic acid furnished the title compounds. All compound exhibited anti-inflammatory activity at the dose 10 mg/kg. The structures of all these newly synthesized compounds were confirmed by their elemental analyses (C, H, N) and spectral data (IR and 1 H NMR).

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“…Non steroidal anti-inflammatory drugs (NSAIDs) have been used for the treatment of ailments such as pain, fever and inflammation and also in chronic conditions such as arthritis, psoriasis and asthma [115][116][117][118][119][120] . NSAIDs principally act by two different mechanisms: a direct contact mechanism on the gastro intestinal (GI) mucosa through oral dose and a generalized systemic action appearing after intravenous dosing 121,122 .…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Medicinal significance of benzothiazole scaffold: an insight view

Sharma

Sinhmar

Sharma

et al. 2012

Journal of Enzyme Inhibition and Medicinal Chemistry

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106

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Synthesis of some novel 2,5-disubstituted thiazolidinones from a long chain fatty acid as possible anti-inflammatory, analgesic and hydrogen peroxide scavenging agents

Cited by 26 publications

References 28 publications

Synthesis, characterization and antimicrobial evaluation of novel azole based (Benzoic Acid) derivatives

Synthesis, characterization and antimicrobial evaluation of novel azole based (Benzoic Acid) derivatives

Synthesis of 2-(aryl)-5-(arylidene)-4-thiazolidinone derivatives with potential analgesic and anti-inflammatory activity

Medicinal significance of benzothiazole scaffold: an insight view

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