Synthesis of some new thiazole derivatives of pharmaceutical interest

Synthesis of Some Thiazolyl and Thiadiazolyl Derivatives of Substituted Furan and Pyrrole.

“…Found: C,52.33;H,4.53;N,11.26. Ethyl 2-methyl-5-((4-p-tolylthiosemicarbazido) 11;H,5.54;N,12.17. Found: C,58.91;H,5.70;N,11.90.…”

“…Recently certain thiadizolines and thiosemicarbazones have been reported to exhibit antiviral and antibacterial properties and were evaluated for biological activity against various microorganisms [3]. Also several of these derivatives likewise, compounds possessing a thiazoline moiety often exhibit additional biological activities [19] including anti-inflammatory, antimicrobial, antitumor or antifungal activities as well as inotropic and chronotropic activities [4][5][6][7][8][9][10][11][12][13][14]. In addition there have been some reports concerning biological interest for furans, pyrroles and their derivatives [2,[15][16][17][18].…”

Progress in the chemistry of 4‐ thiazolidinones

“…El-desoky et al reported the oxidation of 2-(3-methyl-5-oxo-1-phenyl-1,5-dihydro pyrazol-4-ylidene)-3-phenylthiazolidin-5-one (82) with selenium dioxide (SeO 2 ) to afford the corresponding thiazolidin-4,5-dione 83 [99]. …”

On the selenepin/benzene selenide valence tautomerizations: electronic and steric effects at theoretical levels

“…The structures of organo-selenium compounds are mentioned in the literature as being similar to those of organo-sulfur compounds, but their properties present significant differences, and perhaps, because of the toxicity and instability of many Se compounds, their synthesis is much less developed. Organo-selenium compounds, mainly benzisoselenazol-3(2H)-ones and other cyclic selenenamides, seleninate esters, spirodioxyselenuranes, selenium-containing nucleoside analogs, selenazines, and selenazoles, have been tested as antibacterial, antiviral, antifungal, antiparasitic, anti-inflammatory, antihistamine, and anticancer agents [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Moreover, the heterocyclic compounds with selenium atom in the ring such as selenirenes, selenophenes, selenadiazoles, selenatriazoles, benzisoselanazolones, and some others are presented as the reagents and intermediates employed in synthesis of alkenes, alkynes, and nonselenium heterocycles or as the catalysts for hydroperoxide oxidation of various groups of organic compounds [23].…”