Synthesis of some new pyrido[2,3-d]pyrimidines and their ribofuranosides as possible antimicrobial agents

Six‐Membered Heterocycles: 1,2‐, 1,3‐, and 1,4‐Diazines and Related Systems

“…Halide displacement by the Grignard alkyl group triggers ring opening to an imino oxime, which undergoes electrocyclization and methanol elimination to the pyrimidine 92. In related fashion, Kumar and coworkers [113] have reported the conversion of 2-amino-3-cyanopyridines into aminopyrimidinethiones 95 in good yield by cyclization with thiourea (Scheme 19.80).…”

Six‐Membered Heterocycles: 1,2‐, 1,3‐, and 1,4‐Diazines and Related Systems

“…Halide displacement by the Grignard alkyl group triggers ring opening to an imino oxime, which undergoes electrocyclization and methanol elimination to the pyrimidine 92. In related fashion, Kumar and coworkers [113] have reported the conversion of 2-amino-3-cyanopyridines into aminopyrimidinethiones 95 in good yield by cyclization with thiourea (Scheme 19.80).…”

[Bmim]BF 4 : A Versatile Ionic Liquid for the Synthesis of Diverse Bioactive Heterocycles

“…Recently, pyrido[2, 3‐ d ]pyrimidines have gained immense importance because of their widepharmacological efficacies that include antibacterial, antiviral, antimicrobial, anti‐inflammatory, antitumour, antihypertensive etc. activities . Du et al .…”

Synthesis and Antibacterial Activity of a New Series of 2,3,5,7-Substituted-pyrido[2,3-d]pyrimidin-4(3H)-one Derivatives

“…Pyrido [2,3-d]pyrimidine ring system is present in a number of biologically active compounds which includes, antibacterial, [1][2][3] antitumor, 4) antipyretic, 5) analgesic, 6) antihistaminic, [7][8][9] phosphodiesterase-4 (PDE4) inhibitor, 10) adenosine kinase inhibitor, 11) tyrosine kinase inhibitor 12) and diuretic 13,14) activities. More specifically pyrido [2,3-d]pyrimidines were considered as inhibitors of Pneumocystis carinii, Toxoplasma gondii of tumor cells in culture this activity is mainly due to inhibition of dihydrofolate reductase (DHFR) enzyme.…”

Six‐Membered Heterocycles: 1,2‐, 1,3‐, and 1,4‐Diazines and Related Systems

“…Halide displacement by the Grignard alkyl group triggers ring opening to an imino oxime, which undergoes electrocyclization and methanol elimination to the pyrimidine 92. In related fashion, Kumar and coworkers [113] have reported the conversion of 2-amino-3-cyanopyridines into aminopyrimidinethiones 95 in good yield by cyclization with thiourea (Scheme 19.80).…”

[Bmim]BF 4 : A Versatile Ionic Liquid for the Synthesis of Diverse Bioactive Heterocycles

“…Recently, pyrido[2, 3‐ d ]pyrimidines have gained immense importance because of their widepharmacological efficacies that include antibacterial, antiviral, antimicrobial, anti‐inflammatory, antitumour, antihypertensive etc. activities . Du et al .…”

Synthesis and Antibacterial Activity of a New Series of 2,3,5,7-Substituted-pyrido[2,3-d]pyrimidin-4(3H)-one Derivatives

“…Pyrido [2,3-d]pyrimidine ring system is present in a number of biologically active compounds which includes, antibacterial, [1][2][3] antitumor, 4) antipyretic, 5) analgesic, 6) antihistaminic, [7][8][9] phosphodiesterase-4 (PDE4) inhibitor, 10) adenosine kinase inhibitor, 11) tyrosine kinase inhibitor 12) and diuretic 13,14) activities. More specifically pyrido [2,3-d]pyrimidines were considered as inhibitors of Pneumocystis carinii, Toxoplasma gondii of tumor cells in culture this activity is mainly due to inhibition of dihydrofolate reductase (DHFR) enzyme.…”

Six‐Membered Heterocycles: 1,2‐, 1,3‐, and 1,4‐Diazines and Related Systems

“…Halide displacement by the Grignard alkyl group triggers ring opening to an imino oxime, which undergoes electrocyclization and methanol elimination to the pyrimidine 92. In related fashion, Kumar and coworkers [113] have reported the conversion of 2-amino-3-cyanopyridines into aminopyrimidinethiones 95 in good yield by cyclization with thiourea (Scheme 19.80).…”

[Bmim]BF 4 : A Versatile Ionic Liquid for the Synthesis of Diverse Bioactive Heterocycles

“…Recently, pyrido[2, 3‐ d ]pyrimidines have gained immense importance because of their widepharmacological efficacies that include antibacterial, antiviral, antimicrobial, anti‐inflammatory, antitumour, antihypertensive etc. activities . Du et al .…”

Synthesis and Antibacterial Activity of a New Series of 2,3,5,7-Substituted-pyrido[2,3-d]pyrimidin-4(3H)-one Derivatives

“…Pyrido [2,3-d]pyrimidine ring system is present in a number of biologically active compounds which includes, antibacterial, [1][2][3] antitumor, 4) antipyretic, 5) analgesic, 6) antihistaminic, [7][8][9] phosphodiesterase-4 (PDE4) inhibitor, 10) adenosine kinase inhibitor, 11) tyrosine kinase inhibitor 12) and diuretic 13,14) activities. More specifically pyrido [2,3-d]pyrimidines were considered as inhibitors of Pneumocystis carinii, Toxoplasma gondii of tumor cells in culture this activity is mainly due to inhibition of dihydrofolate reductase (DHFR) enzyme.…”