volume 6, issue 1, P63-70 2015
DOI: 10.5155/eurjchem.6.1.63-70.1147
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Abdulrahman Salim Al-Harbi,
Reda Mohammady Abdel-Rahman,
Abdullah Mohamed Asiri

Abstract: New potential enzyme inhibitors, fluorine-substituted thiobarbituric acid derivatives (2, 3, 9, 8 and 12) and their fused/isolated heterocyclic nitrogen systems (5, 6, 10 and 14) have been obtained from heterocyclization of fluorinated N, Nʹ-disubstituted thiourea (1, 7 and 11) with malonic acid followed by ring closure reactions with primary nitrogen reagents. Structures of the synthesized products have been deduced from their elemental analysis and spectral data. Anti-HIV-1 and inhibition of cyclin-dependen…

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