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“…4 Furthermore, substituted 1,3,4-oxadiazole derivatives also have been reported to show broad spectrum bioactivities including insecticidal, 5 antibacterial, 6 anticancer, 7 and anti-inflammatory activities. 8 On the other hand, recently the synthesis and bioactivity of gallic acid derivatives have attracted more and more attention, among which some hydrazone and 1,3,4-oxadiazole derivatives containing 3,4,5-trimethoxyphenyl moiety with certain antimicrobial activity were reported. 9 However, in our previous work, some 1,3,4-thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety were proved having good antitumor bioactivity.…”
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“…4 Furthermore, substituted 1,3,4-oxadiazole derivatives also have been reported to show broad spectrum bioactivities including insecticidal, 5 antibacterial, 6 anticancer, 7 and anti-inflammatory activities. 8 On the other hand, recently the synthesis and bioactivity of gallic acid derivatives have attracted more and more attention, among which some hydrazone and 1,3,4-oxadiazole derivatives containing 3,4,5-trimethoxyphenyl moiety with certain antimicrobial activity were reported. 9 However, in our previous work, some 1,3,4-thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety were proved having good antitumor bioactivity.…”
mentioning
“…Furthermore substituted 1,3,4-oxadiazole derivatives also have been reported to show broad spectrum of biological activities including anticancer [9], antibacterial [10], anti-inflammatory and analgesic activities [11][12][13][14][15][16][17]. It was of interest to convert the free carboxylic function of these aroylpropionic acid derivatives into 1,3,4-oxadiazole nucleus and screen the synthesized compounds for their biological activity.…”
Section: Introductionmentioning
“…Incorporation of potential 6-methoxy-2-naphthalene moiety may enhance biological activity of 1,3,4-oxadiazole derivatives. As a continuation of our urge to find out biologically active potential 1,3,4-oxadiazoles [13], we decided to synthesize some new 2-(6-methoxy-2-naphthyl)-5-aryl-1, 3,4-oxadiazoles and study their anti-inflammatory and analgesic activities.…”
Section: Introductionmentioning