Synthesis of Some New Benzothiazol‐2‐yl‐Benzylidene‐Imines and their Antibacterial Activity

Abstract

Nowel benzothiazol‐2‐yl‐benzylidene imines are synthesized by condensation of benzaldehydes and corresponding 2‐aminobenzothiazoles. Condensation of benzaldehyde 1a and 2‐aminobenzothiazoles 2(a,b) gave benzothiazol‐2‐yl‐benzylidene imines 3(a,b). By condensation of 3‐nitrobenzaldehyde 1b and 2‐aminobenzothiazoles 3(a,b) , corresponding benzothiazol‐yl‐3‐nitrobenzylidene imines 3(c, d) were synthesized. The antibacterial activity of products 4(a‐d) were investigated and results were submitted for their activities against E. coli, Clebsiella and S. aureus. Compound 3d showed light bactericide activity against S. aureus. Emphatic activity against E. coli exhibited compounds 3d and 3c , whereas 3d and 3b exhibited the strongest activity against Clebsiella. In general there was a direct positive correlation between increasing concentration of the compound and antibacterial activity.