Synthesis of some New 4‐Pyridinylylamino‐ and 4‐Pyrimidinylamino‐3‐Nitro‐2H‐[1]‐Benzopyran‐2‐ones and their Antibacterial Activity

Abstract

4‐(4′‐metoxy‐2‐Benzothiazolylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 4a, 4‐(6′‐nitro‐2‐Benzothiazolylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 4b, 4‐(6′‐fluoro‐2‐Benzothiazolylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 4c and substitued 4‐(1,2,4‐triazolyl‐3‐amino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐ones 4(d‐e) are synthetized by condensation of 4‐Chlor‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 2 and corresponding heteroarylamines 3(a–e) under the reflux reaction conditions. Alkali hydrolysis of 4(a–e) afforded the 2‐hydroxy‐ù‐nitroacetophenone 5. Microbiological activity of products 4(a–d) are investigated and results are submitted for their activities against Staphylococcus aureus, Escherichia coli and Clebsiella.

Synthesis of Some New 4-(Benzothiazolylamino)-Pyran-2-One Derivatives and Their Antibacterial Activity

“…On the other hand, the extraordinary biologically importance of benzothiazole derivatives has generated a constant interest for their synthesis and research. In continuation of our previous studies and in an attempt to synthesize the new derivates [15][16][17] in this paper we had intended to synthesize some new heterocyclic derivatives by condensation of 4-chloro-6-methyl-2H-pyran-2-one and substituted 2-aminobenzothiazole which could serve as propharmaceutical products.…”