Synthesis of pyrimidine derivatives via multicomponent reaction catalyzed by ferric chloride

Abstract

An eco-friendly and practical approach was developed for the synthesis of pyrimidine derivatives via a one-pot, three-component coupling reaction of commercially available aldehydes, alkynes, and indazole3/triazole catalyzed by ferric chloride with good to excellent yields. The advantages of this method include environmentally friendly catalyst, easily available materials, and ease of product isolation.

Recent advances in the application of alkynes in multicomponent reactions

“…Xian et al 79 synthesized 2,4-diphenylpyrimido[1,2- b ]indazole derivatives 162 via the reaction among alkyne derivatives 161, 1 H -indazol-3-amine 159, and aldehydes 160 under solvent-free conditions in the presence of FeCl 3 at 110 °C ( Scheme 68 ).…”

Synthesis and Characterization of Hexahydropyrimidines and Their New Derivatives

“…This class of compounds frequently showcases noteworthy biological activities and holds considerable relevance in clinical applications (Tolba et al 2022). As a result, pyrimidine derivatives have been widely used as bioactive compounds in medicinal chemistry for their anticancer, anti-inflammatory, antibacterial, and antivirus properties (Xian et al 2020).…”