Synthesis of Polyalkylguanidine Hydrochloride Copolymers and Their Antibacterial Activity Against Conditionally Pathogenic Microorganisms Bacillus Cereus and Escherichia Coli

Abstract

Copolymers based on aliphatic diamines of various methylene chain lengths and guanidine hydrochloride were prepared by polycondensation in the melt. Antibacterial activity of water-soluble copolymers based on guanidine against conditionally pathogenic microorganisms Escherichia coli and Bacillus cereus was evaluated using diffusion in agar. A relationship was found between the ratio of the number of hydrophobic methylene groups to the number of ionized guanidines and the antibacterial activity of the copolymers. Several samples showed high antimicrobial activity as compared with polyhexamethyleneguanidine hydrochloride (PHMGHC), which is widely used as a medical disinfectant.

Synthesis and antibacterial properties of a novel magnetic nanocomposite prepared from spent pickling liquors and polyguanidine

“…7 . It can be seen that sole polyguanidine with a concentration of 5.0 mg mL −1 presented an inhibition zone of 14 mm in diameter, which is almost the same as that reported by Grigor'eva et al 27 On the other hand, the Fe 3 O 4 nanoparticles exhibited no antibacterial activity. The synthesized Fe 3 O 4 /polyguanidine nanocomposite had a relatively high antibacterial effect, presenting an inhibition zone of about 10 mm when the concentration was 5.0 mg mL −1 .…”

“…The broad peak at around 3449 cm −1 of Fe 3 O 4 was also displaced to 3408 cm −1 because of the overlap with the peak of the N–H vibration from polyguanidine. 27 …”

Conductometry biotesting as applied to valuation of the pro- and antibacterial properties of catolites and anolites

“…При этомв качестве последних, могут быть применены как одноклеточные, так и более высокоорга-низованные организмы (планктон, грибы, растения, рыбы, птицы, крысы и другие млекопитающие) [1][2][3][4][5][6][7]. Но, хотя использование для целей биотестирования многоклеточных организмов позволяет более адек-ватно моделировать с их помощью человеческий организм, это делает проведение таких анализов значи-тельно более сложным, дорогим, длительным и субъективным в оценке результатов.…”

Wound-healing activity of polyhexamethyleneguanidine hydrochloride hydrogel and extract of Bergenia crassifolia on thermal burn simulation

“…As drug carriers, polymer hydrogels have gained increasing interest [4][5][6][7]. There has been tremendous interest in polyguanidines because of their high antibacterial properties, low toxicity and ability to form highly swollen hydrogels that can be complexed [8][9][10][11]. In our previous study, we demonstrated that the gels exhibit wound-healing effects comparable to those of widely used chloramphenicol and methyluracil preparations [12,13].…”