Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity

Alam, Mohammad Sayed; Choi, Jae-Sung; Lee, Dong‐Ung

doi:10.1016/j.bmc.2012.04.058

Cited by 160 publications

(65 citation statements)

References 21 publications

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“…Lipopolysaccharide (LPS), an endotoxin which is derived from the cell wall of Gram-negative bacteria, can induce multiple signaling pathways to stimulate the production of inflammatory modulators involving NO, PGE 2 , TNF-, and interleukins. The results indicated that 50 g/mL of 25f inhibited the LPS-stimulated COX-2 mRNA levels [43].…”

Section: Anticonvulsant Activity a Series Of Schiff Bases Of Phthalimentioning

confidence: 90%

Schiff Bases: A Versatile Pharmacophore

Kajal

Bala

Kamboj

et al. 2013

Journal of Catalysts

319

196

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Schiff bases are condensation products of primary amines with carbonyl compounds gaining importance day by day in present scenario. Schiff bases are the compounds carrying imine or azomethine (-C=N-) functional group and are found to be a versatile pharmacophore for design and development of various bioactive lead compounds. Schiff bases exhibit useful biological activities such anti-inflammatory, analgesic, antimicrobial, anticonvulsant, antitubercular, anticancer, antioxidant, anthelmintic, antiglycation, and antidepressant activities. Schiff bases are also used as catalysts, pigments and dyes, intermediates in organic synthesis, polymer stabilizers, and corrosion inhibitors. The present review summarizes information on the diverse biological activities and also highlights the recently synthesized numerous Schiff bases as potential bioactive core.

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Section: Anticonvulsant Activity a Series Of Schiff Bases Of Phthalimentioning

confidence: 90%

Schiff Bases: A Versatile Pharmacophore

Kajal

Bala

Kamboj

et al. 2013

Journal of Catalysts

319

196

View full text Add to dashboard Cite

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“…The newly prepared compounds 3a-g, 5a-d as well as previously synthesized compounds 3h-l [7] were evaluated for their antioxidant activities. Nowadays a lot of attention is devoted to the study of antiradical activity of various Schiff bases, e.g., thymol and carvacrol based imines [8] and 4-aminoantipyrine derivatives [9]. We were interested in finding out the possible antiradical activity of imines containing quinozolinone moiety.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Antioxidant Properties of Novel Quinazoline Derivatives

Tetere

Zicāne

Ravina

et al. 2014

Material Science and Applied Chemistry

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-Quinazoline derivatives have expressed a broad spectrum of biological activities, but there are few examples in literature on an antioxidant activity of different quinazolines. On the basis of literature by Chinese scientists on the effective antioxidant activity of Schiff bases containing 2-oxoquinoline and due to structural similarity of quinoline and quinazoline ring systems, the reactions of 3-aminoquinazolinone with a range of aromatic aldehydes and ethoxymethylene derivatives have been carried out and their radical scavenging activities have been studied.

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“…Dokuları bu hasarlardan koruyabilmek için serbest radikallerin etkisiz duruma getirilmesi önemlidir [6]. Bu nedenle, antioksidanların birçok ölümcül hastalığa karşı insanları korumada önemli bir rol oynadığı gösterilmiştir [7]. Antioksidanlar (Şekil 1), gıdalarda veya vücutta düşük derişimlerde bulunduğunda bir hedef molekülün oksidatif hasarını geciktiren, engelleyen veya ortadan kaldıran maddeler olarak tanımlanmaktadır [8,9].…”

Section: Gi̇ri̇ş (Introduction)unclassified

Sinnamaldehitin yeni schiff bazlarının sentezi ve antioksidan özelliklerinin incelenmesi

Kurt

2018

Sakarya University Journal of Science

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ÖZBu çalışmada, sinnamaldehitin 9 yeni schiff bazı sentezlenmiş ve bu bileşiklerin 2,2-difenil-1-pikrilhidrazil radikal söndürücü kapasitesi (DPPH), Troloks eşdeğeri antioksidan kapasitesi (ABTS) ve bakır (II) iyonu indirgeyici antioksidan kapasitesi (CUPRAC) olmak üzere üç farklı yöntemle antioksidan aktivite özellikleri incelenmiştir. Bu bileşiklerin içinde (2,3-dihidroksibenziliden)amino)fenil)-5-fenilpenta-2,4-dien-1-on (4c) bileşiği her üç yönteme göre oldukça etkin bir şekilde antioksidan özellik göstermiştir. Ayrıca sentezlenen bileşiklerin yapı aktivite ilişkisi incelenerek bileşiklerin sahip oldukları grupların antioksidan aktiviteyi hangi yönde etkilediği ortaya konulmuştur. Anahtar kelimeler: Sinnamaldehit, Schiff bazı, Antioksidan aktivite Synthesis and antioxidant activities of new schiff bases of Cinnamaldehyde ABSTRACTIn this study, 9 new schiff bases of cinnamaldehyde were synthesized and their antioxidant activities were examined by DPPH, ABTS and CUPRAC. Among the synthesized compounds, (2,3-dihydroxybenzylidene)amino)phenyl)-5-phenylpenta-2,4-dien-1-one (4c) showed high effective antioxidant activity for all three methods. In addition, the structure activity relationship of the synthesized compounds was examined, and it was revealed how the groups possessed by the compounds had an effect on antioxidant activity.

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Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti-inflammatory activity

Cited by 160 publications

References 21 publications

Schiff Bases: A Versatile Pharmacophore

Schiff Bases: A Versatile Pharmacophore

Synthesis and Antioxidant Properties of Novel Quinazoline Derivatives

Sinnamaldehitin yeni schiff bazlarının sentezi ve antioksidan özelliklerinin incelenmesi

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