Synthesis of Novel Phosphoramide-Tegafur Derivatives Containing Aminopropylsilatrane

Synthesis and reactivity of novel 3-isothiocyanatopropylsilatrane derived from aminopropylsilatrane: X-ray crystal structure and theoretical studies

“…The starting material 1 was synthesized according to the method reported in literature [14,15]. 3-Aminopropyl(triethoxy)silane (5.00 g, 22.5 mmol) was added to triethanolamine (3.36 g, 22.5 mmol) at room temperature in a two-necked flask which was fitted with a Dean Stark trap.…”

“…Perhaps the most intriguing aspect of these hypercoordinate silicon compounds is the nature of the silicon-nitrogen interaction and the variation in the transannular Si-N distance as a function of change in the axial silicon substituent [2][3][4][5][6][7][8][9]. Aminopropylsilatranes are potential precursor materials for the synthesis of a number of N-derivative silatranes [10][11][12][13][14][15]. These derivatives of aminopropylsilatranes find applications as fungicides [13,14], anticancer and antitumour agents [15,16].…”

“…Aminopropylsilatranes are potential precursor materials for the synthesis of a number of N-derivative silatranes [10][11][12][13][14][15]. These derivatives of aminopropylsilatranes find applications as fungicides [13,14], anticancer and antitumour agents [15,16]. The aminopropylsilatranes have also been used for immobilization of DNA due to less reactivity, extremely resistant behavior to hydrolysis and polymerization at neutral pH [17].…”

Polyethylenimine-cyclodextrin-tegafur conjugate shows anti-cancer activity and a potential for gene delivery

“…Compared to other hydroxyalkylation procedures using toxic chlorohydrine (Shi et al, 2005;Zhang et al, 2007) or bromhydrin (He et al, 2000), hydroxymethylation conducted by formaldehyde takes place in a milder way with high yield. And then hydroxymethyl tegafur activated by CDI was successfully conjugated to PEI-CyD copolymer.…”

Reactivity of 1-Isothiocyanato Six Membered Silatrane towards Transition Metal Carbonyls

“…Silatranes are valuable objects for medicinal chemistry [11,12] owing to the broad spectrum of biological activities they possess. They find applications as bactericides [13] and fungicides [14], as anticancer [15] and antitumour [16] agents and are also useful for immobilizations of DNA [17].…”