2014
DOI: 10.1002/jhet.2209
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Abstract: in Wiley Online Library (wileyonlinelibrary.com).In the present study, we have made an effort to develop the novel synthetic antioxidants and antimicrobials with improved potency. The novel benzofuran-gathered C-2,4,6-substituted pyrimidine derivatives 5-9(a-f) were synthesized by simple and efficient four-step reaction pathway. Initially, o-alkyl derivative of salicylaldehyde readily furnish corresponding 2-acetyl benzofuran 2 in good yield, upon the treatment with potassium tertiary butoxide in the presence … Show more

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Cited by 7 publications
(4 citation statements)
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“…2b) possessed maximum radical activity as well as were more potent than the standard when 4-hydroxyphenyl substitution at S-linked C-2 and C-6 positions of pyrimidine was present as well as with 4-hydroxy-3-methoxyphenyl substitution at C-6 position of pyrimidine. IC 50 (DPPH) values of these compounds were 08 and 10 micro molar respectively [44] .…”
Section: Lead Compound As Antioxidant Templatesmentioning
confidence: 93%
See 1 more Smart Citation
“…2b) possessed maximum radical activity as well as were more potent than the standard when 4-hydroxyphenyl substitution at S-linked C-2 and C-6 positions of pyrimidine was present as well as with 4-hydroxy-3-methoxyphenyl substitution at C-6 position of pyrimidine. IC 50 (DPPH) values of these compounds were 08 and 10 micro molar respectively [44] .…”
Section: Lead Compound As Antioxidant Templatesmentioning
confidence: 93%
“…Rangaswamy et al [44] synthesized series of novel 2,4,6-substituted pyrimidine derivatives conjugated by sulfonyl chloride attached with benzofuran at C-6. All the newly synthesized compounds were evaluated for their antioxidant activity by using three in vitro assays DPPH radical scavenging activity [17] , N,N-dimethylp-phenylenediamine (DMPD) and ferric ion reducing power assay.…”
Section: Lead Compound As Antioxidant Templatesmentioning
confidence: 99%
“…On the basis of the promising initial data and also due to our interests in synthesis of biologically active heterocycles [8][9][10][11] , here a library of novel analogues was synthesized. Along with identifying the structural parameters that govern the antioxidant and antibacterial properties.…”
Section: Figure 1 General Structure Of Bioactive Quinazolinesmentioning
confidence: 99%
“…Preparation of compounds was started from the methoxy-salicylaldehyde (1) that underwent cyclo condensation reaction with chlroacetone in DCM at room temperature by using DBU as the base thus obtaining intermediates 1-(6-methoxy benzofuran-2-yl) ethanone (2) [24]. Chalcone was synthesized from the (2) with nitro benzaldehyde by Claisen-Schmidt condensation under zirconium chloride as a catalyst thus yielding (3) [25].…”
Section: Chemistrymentioning
confidence: 99%