Synthesis of novel 3-formamido-3-acylamino-monobactams

Branch, Clive L.; Finch, Stephen C.; Pearson, Michael J.

doi:10.1016/s0040-4039(00)99206-2

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…found that α‐formamido substituents conferred β‐lactamase stability, while retaining antibacterial activity. Therefore, they examined the synthesis and biological evaluation of some novel 3‐formamido‐3‐acylaminomonobactams . Unfortunately, their aminothiazolyl derivative 19 showed only poor antibacterial activity against E. coli , S. marcescens , Klebsiella aerogenes , E. cloacae , and Pseudomonas morganii (Fig.…”

Section: Monobactamsmentioning

confidence: 99%

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Antibacterial and β‐Lactamase Inhibitory Activity of Monocyclic β‐Lactams

Decuyper

Jukič

Sosič

et al. 2017

Medicinal Research Reviews

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Due to the widespread emergence of resistant bacterial strains, an urgent need for the development of new antibacterial agents with novel modes of action has emerged. The discovery of naturally occurring monocyclic β-lactams in the late 1970s, mainly active against aerobic Gram-negative bacteria, has introduced a new approach in the design and development of novel antibacterial β-lactam agents. The main goal was the derivatization of the azetidin-2-one core in order to improve their antibacterial potency, broaden their spectrum of activity, and enhance their β-lactamase stability. In that respect, our review covers the updates in the field of monocyclic β-lactam antibiotics during the last three decades, taking into account an extensive collection of references. An overview of the relationships between the structural features of these monocyclic β-lactams, classified according to their N-substituent, and the associated antibacterial or β-lactamase inhibitory activities is provided. The different paragraphs disclose a number of well-established classes of compounds, such as monobactams, monosulfactams, monocarbams, monophosphams, nocardicins, as well as other known representative classes. Moreover, this review draws attention to some less common but, nevertheless, possibly important types of monocyclic β-lactams and concludes by highlighting the recent developments on siderophore-conjugated classes of monocyclic β-lactams.

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Section: Monobactamsmentioning

confidence: 99%

“…were also interested in 3‐acylaminomonobactam 27 (Fig. , Table ) . As opposed to compound 19 , this derivative did possess a moderate antibacterial activity in a standard microtitre minimum inhibitory concentration test against E. coli , S. marcescens , K. aerogenes , E. cloacae , and P. morganii strains (MICs of 3.2–25 μg/mL).…”

Section: Monobactamsmentioning

confidence: 99%