Synthesis of Minigramicidin Ion Channels and Test of Their Hydrophobic Match with the Membrane

Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thickness

“…This finding is also consistent with the idea that patch rupture is a stochastic event that requires a finite time to occur. A related consideration concerns the observation that full-sized gA channels form readily not only in PC-16 but also in PC-14 bilayers (40). Furthermore, CD measurements indicate gA dimers form in bilayers with acyl chain lengths as short as 10 (44).…”

Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thickness

“…This finding is also consistent with the idea that patch rupture is a stochastic event that requires a finite time to occur. A related consideration concerns the observation that full-sized gA channels form readily not only in PC-16 but also in PC-14 bilayers (40). Furthermore, CD measurements indicate gA dimers form in bilayers with acyl chain lengths as short as 10 (44).…”

Spatially controlled self-assembly of gold nanoparticles encased in α-helical polypeptide nanospheres

“…For example, they may serve as non-insulating cages, since properly designed a-helices are known to mediate transport of electrons 10,11 and ions. 12,13 In this communication, we show that two typical spatial supramolecular organizations of gold nanoparticles (Au-NPs) are separately formed via the emulsion-templated interfacial selfassembly process. Au-NPs are either assembled in the central core of peptide nanospheres or accumulated on the inner wall of hollow capsules.…”

Ionic conductance of synthetic channels: analysis, lessons, and recommendations

“…However, a different type of ''inactive'' gramicidin is known. 107 So-called ''mini-gramicidins'' are active only in thinner bilayers (e.g. DMPC) but inactive in normal bilayers.…”

Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thickness

“…This finding is also consistent with the idea that patch rupture is a stochastic event that requires a finite time to occur. A related consideration concerns the observation that full-sized gA channels form readily not only in PC-16 but also in PC-14 bilayers (40). Furthermore, CD measurements indicate gA dimers form in bilayers with acyl chain lengths as short as 10 (44).…”

Spatially controlled self-assembly of gold nanoparticles encased in α-helical polypeptide nanospheres

“…For example, they may serve as non-insulating cages, since properly designed a-helices are known to mediate transport of electrons 10,11 and ions. 12,13 In this communication, we show that two typical spatial supramolecular organizations of gold nanoparticles (Au-NPs) are separately formed via the emulsion-templated interfacial selfassembly process. Au-NPs are either assembled in the central core of peptide nanospheres or accumulated on the inner wall of hollow capsules.…”

Ionic conductance of synthetic channels: analysis, lessons, and recommendations

“…However, a different type of ''inactive'' gramicidin is known. 107 So-called ''mini-gramicidins'' are active only in thinner bilayers (e.g. DMPC) but inactive in normal bilayers.…”

Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thickness

“…This finding is also consistent with the idea that patch rupture is a stochastic event that requires a finite time to occur. A related consideration concerns the observation that full-sized gA channels form readily not only in PC-16 but also in PC-14 bilayers (40). Furthermore, CD measurements indicate gA dimers form in bilayers with acyl chain lengths as short as 10 (44).…”

Spatially controlled self-assembly of gold nanoparticles encased in α-helical polypeptide nanospheres

“…For example, they may serve as non-insulating cages, since properly designed a-helices are known to mediate transport of electrons 10,11 and ions. 12,13 In this communication, we show that two typical spatial supramolecular organizations of gold nanoparticles (Au-NPs) are separately formed via the emulsion-templated interfacial selfassembly process. Au-NPs are either assembled in the central core of peptide nanospheres or accumulated on the inner wall of hollow capsules.…”

Ionic conductance of synthetic channels: analysis, lessons, and recommendations

“…However, a different type of ''inactive'' gramicidin is known. 107 So-called ''mini-gramicidins'' are active only in thinner bilayers (e.g. DMPC) but inactive in normal bilayers.…”