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“…Concerning the cannabinoid counterpart of the proposed hybrid molecules, good affinities for the CB 1 receptor have been reported for diarylcarboxamides bearing alkyl chains (Figure 2). 15,16…”
Section: Introductionmentioning
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“…Concerning the cannabinoid counterpart of the proposed hybrid molecules, good affinities for the CB 1 receptor have been reported for diarylcarboxamides bearing alkyl chains (Figure 2). 15,16…”
Section: Introductionmentioning
“…Also deracoxib (Deramaxxe) is already used for the treatment of pain and inflammation in dogs [2,3]. Furthermore, there are various reports which have demonstrated the analgesic-antiinflammatory effects of pyrazole derivatives [4][5][6][7][8][9][10][11][12][13].…”
Section: Introductionmentioning
“…These com- jpet.aspetjournals.org pounds also exhibited the greatest CB 1 receptor selectivity, suggesting that the carboxamide oxygen may play a role in residual CB 2 receptor affinity of rimonabant and its analogs that contain it (see Table 1). Nevertheless, compared with compounds possessing only nitrogen-containing substituents (e.g., O-6729, O-6731, and O-6740), better CB 1 affinity was observed for compounds with a carboxamide substituent (e.g., O-4333 and O-4334) (Thomas et al, 1998(Thomas et al, , 2005Gullapalli et al, 2010). The enhanced affinity shown here by the pyrazole analogs possessing agonist-like effects suggests that the basis for the differences in affinities resides in the structural (versus functional) properties of the compound.…”
Section: Discussionmentioning