Synthesis of hybrid colloidal nanoparticles for a generic approach to 3D electrostatic directed assembly: Application to anti-counterfeiting

Platel, Romain; Vaure, Louis; Palleau, Etienne; Raffy, Simon; Guérin, François; Lagarde, Delphine; Cours, Robin; Marcelot, Cécile; Warot-Fonrose, Bénédicte; Nayral, Céline; Delpech, Fabien; Ressier, Laurence

doi:10.1016/j.jcis.2020.08.098

Cited by 18 publications

(14 citation statements)

References 40 publications

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“…The mean fluorescence intensities of DMEM (with 5% FBS), Cur-solution, Cur-NPs, and Cur-P-NPs after coculture with U251 cells for 3 h were 518. 33 show green fluorescence; most of the U251 cells in this group were shuttle-shaped with better cell morphology than those in the other groups. The intracellular fluorescence intensity was the greatest in the Cur-P-NP group and the weakest in the Cur-NP group.…”

Section: Cellular Uptakementioning

confidence: 73%

“…Hybrid nanoparticles act as multifunctional drug delivery systems, owing to the heterogeneous assembly of different polymers that retain their specific properties. 33 This delivery system combines the advantages of multiple nanoparticles (with different particle sizes, potentials, and morphologies) for drug delivery, exhibiting collective properties different from those of single nanoparticles. 34 Nanoparticles of uniform size can be continuously prepared using microchannels.…”

Section: Introductionmentioning

confidence: 99%

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Curcumin-Loaded Hybrid Nanoparticles: Microchannel-Based Preparation and Antitumor Activity in a Mouse Model

Hong¹,

Gao²,

Lou³

et al. 2021

IJN

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Purpose To develop microchannel-based preparation of curcumin (Cur)-loaded hybrid nanoparticles using enzyme-targeted peptides and star-shaped polycyclic lipids as carriers, and to accomplish a desirable targeted drug delivery via these nanoparticles, which could improve the bioavailability and antitumor effects of Cur. Methods The amphiphilic tri-chaintricarballylic acid-poly (ε-caprolactone)-methoxypolyethylene glycol (Tri-CL-mPEG) and the enzyme-targeted tetra-chain pentaerythritol-poly (ε-caprolactone)-polypeptide (PET-CL-P) were synthesized. The Cur-loaded enzyme-targeted hybrid nano-delivery systems (Cur-P-NPs) were prepared by using the microfluidic continuous granulation technology. The physicochemical properties, release behavior in vitro, and stability of these Cur-P-NPs were investigated. Their cytotoxicity, cellular uptake, anti-proliferative efficacy in vitro, biodistribution, and antitumor effects in vivo were also studied. Results The particle size of the prepared Cur-P-NPs was 146.1 ± 1.940 nm, polydispersity index was 0.175 ± 0.014, zeta potential was 10.1 ± 0.300 mV, encapsulation rate was 74.66 ± 0.671%, and drug loading capacity was 5.38 ± 0.316%. The stability of Cur-P-NPs was adequate, and the in vitro release rate increased with the decrease of the environmental pH. Seven days post incubation, the cumulative release values of Cur were 52.78%, 67.39%, and 98.12% at pH 7.4, pH 6.8 and pH 5.0, respectively. Cur-P-NPs exhibited better cell entry and antiproliferation efficacy against U251 cells than the Cur-solution and Cur-NPs and were safe for use. Cur-P-NPs specifically targeted tumor tissues and inhibited their growth (78.63% tumor growth inhibition rate) with low toxic effects on normal tissues. Conclusion The enzyme-targeted hybrid nanoparticles prepared in the study clearly have the tumor-targeting ability. Cur-P-NPs can effectively improve the bioavailability of Cur and have potential applications in drug delivery and tumor management.

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Section: Cellular Uptakementioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Hybrid Nanoparticles: Microchannel-Based Preparation and Antitumor Activity in a Mouse Model

Hong¹,

Gao²,

Lou³

et al. 2021

IJN

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“…At the same time, the SWIR term specifically defines the spectral range beyond 1,500 nm (Golovynskyi et al, 2018), especially in rapidly emerging bioimaging field that utilizes exogenous photoluminescent probes, including Yb 3+ /Er 3+ doped RENPs (Wang et al, 2018a;Lv et al, 2019;Hazra et al, 2020;Li et al, 2020). Along with this, anti-counterfeiting applications of the SWIR emitting nanoparticles have also been recently reported, suggesting PL imaging of 3D patterns and multilevel anti-counterfeiting protection based on imaging through opaque layers (Tan et al, 2020;Platel et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Real-Time Imaging of Short-Wave Infrared Luminescence Lifetimes for Anti-counterfeiting Applications

Ziniuk¹,

Yakovliev²,

Li³

et al. 2021

Front. Chem.

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Rare-earth doped nanoparticles (RENPs) have been widely used for anti-counterfeiting and security applications due to their light frequency conversion features: they are excited at one wavelength, and they display spectrally narrow and distinguished luminescence peaks either at shorter wavelengths (i.e., frequency/energy upconversion) or at longer wavelengths (frequency/energy downconversion). RENPs with a downconversion (DC) photoluminescence (PL) in short-wave infrared (SWIR) spectral range (~1,000–1,700 nm) have recently been introduced to anti-counterfeiting applications, allowing for multilevel protection based on PL imaging through opaque layers, due to a lesser scattering of SWIR PL emission. However, as the number and spectral positions of the discrete PL bands exhibited by rare-earth ions are well-known, it is feasible to replicate luminescence spectra from RENPs, which results in a limited anti-counterfeiting security. Alternatively, lifetime of PL from RENPs can be used for encoding, as it can be finely tuned in broad temporal range (i.e., from microseconds to milliseconds) by varying type of dopants and their content in RENPs, along with the nanoparticle morphology and size. Nevertheless, the current approach to decoding and imaging the RENP luminescence lifetimes requires multiple steps and is highly time-consuming, precluding practical applications of PL lifetime encoding for anti-counterfeiting. Herein, we report the use of a rapid lifetime determination (RLD) technique to overcome this issue and introduce real-time imaging of SWIR PL lifetime for anti-counterfeiting applications. NaYF4:20% Yb, x% Er (x = 0, 2, 20, 80)@NaYF4 core@shell RENPs were synthesized and characterized, revealing DC PL in SWIR region, with maximum at ~1,530 nm and PL lifetimes ranging from 3.2 to 6 ms. Imaging of the nanoparticles with different lifetimes was performed by the developed time-gated imaging system engaging RLD method and the precise manipulation of the delay between the excitation pulses and camera gating windows. Moreover, it is shown that imaging and decrypting can be performed at a high rate (3–4 fps) in a cyclic manner, thus allowing for real-time temporal decoding. We believe that the demonstrated RLD-based fast PL lifetime imaging approach can be employed in other applications of photoluminescent RENPs.

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“…Fluorescent inks are commonly used as second-level security features; being invisible in the daylight and detectable under UV light. In the last decade, to prevent counterfeiting security labels have been created using different printing techniques with various fluorescent inks formulated by using rare earth luminescent materials [1][2][3][4][5][6] , perovskite nanocrystals 7,8 , carbon dots [9][10][11] , organic dyes 12,13 , and quantum dots [14][15][16] . Among various printing methods, screen printing is preferable because it is easily applicable to various substrates 17 .…”

Section: Introductionmentioning

confidence: 99%

An anticounterfeiting technology combining an InP nanoparticle ink and a versatile optical device for authentication

2021

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Synthesis of hybrid colloidal nanoparticles for a generic approach to 3D electrostatic directed assembly: Application to anti-counterfeiting

Cited by 18 publications

References 40 publications

Curcumin-Loaded Hybrid Nanoparticles: Microchannel-Based Preparation and Antitumor Activity in a Mouse Model

Curcumin-Loaded Hybrid Nanoparticles: Microchannel-Based Preparation and Antitumor Activity in a Mouse Model

Real-Time Imaging of Short-Wave Infrared Luminescence Lifetimes for Anti-counterfeiting Applications

An anticounterfeiting technology combining an InP nanoparticle ink and a versatile optical device for authentication

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