J. Labelled Cpd. Radiopharm.
 1999
DOI: 10.1002/(sici)1099-1344(199906)42:6<581::aid-jlcr218>3.0.co;2-m
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Synthesis of (E)-N-(3-bromoprop-2-enyl)-2β-carbomethoxy-3β-(4′-tolyl) nortropane (PE2Br) and radiolabelling of [76Br]PE2Br: a potential ligand for exploration of the dopamine transporter by PET

Julie Helfenbein
1
,
Patrick Emond
2
,
Christian Loc’h
3
et al.

Abstract: In order to study the dopamine transporter by PET, we prepared (E)‐N‐(3‐bromoprop‐2‐enyl)‐2β‐carbomethoxy‐3β‐(4′‐tolyl) nortropane (PE2Br) and its radiobrominated analogue, PE2Br and [76Br]PE2Br were synthesized by bromodestannylation of the tributylstannyl derivative using either N‐bromosuccinimide in THF or [76Br]NHBr with peracetic acid as oxidant respectively. After purification by HPLC, [76Br]PE2Br was obtained with a radiochemical yield of 80%, a radiochemical purity higher than 98% and a specific radioa… Show more

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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