Synthesis of chitosan/brushite powders for bone cement composites

Abstract

Recently, calcium phosphate cements have been considered in medicine and dentistry because of their excellent biocompatibility and advantages in situ handling and shaping abilities. Nevertheless, low mechanical strength of these cements limits wider the clinical applications. The aim of this work was the synthesis of chitosan/brushite powders for preparing the calcium phosphate cements. The synthesis of brushite was carried out in the chitosan matrix from calcium chloride and sodium phosphate at moderate pH of 4 and then dried from 60 to 100°C. The obtained powders were characterized by XRD and FT-IR technique. With increasing the drying temperature, phase of dicalcium phosphate anhydrous increased. Moreover, FTIR indicate the bands attributable to chitosan and brushite. The brushite synthesized using this route was used to be a starting powder for calcium phosphate cement (CPC). To prepare CPC, the mixture of chitisan/brushite and a-tricalcium phosphate powders was mixed with various liquid phases and then cured at 100 humidity for 7 d The compressive strength of the cements was determined to evaluate the potential use for the bone cement. Cements formed with chitosan/brushite dried at 100°C had the greatest compressive strength of all cement tests. The improvement of compressive strength seemed to depend on the affinity of chitosan incorporated in the cements.

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

“…This indicated that the composite fibers formed a unique core-shell structure with shell of CaPO 4 and core of chitosan [ 425 ]. A similar formulation was prepared for further applications in self-setting biocomposites [ 426 ]. DCPA/BSA biocomposites were synthesized through the co-precipitation of BSA on the nanodimensional particles of DCPA performed in ethanol [ 427 ].…”

Biocomposites and hybrid biomaterials based on calcium orthophosphates

“…500 A similar formulation was prepared for further applications in bone cement biocomposites. 501 DCPA/BSA biocomposites were synthesized through the coprecipitation of BSA on the nanodimensional particles of DCPA performed in ethanol. 502 Nanodimensional DCPA was synthesized and incorporated into dental resins to form dental biocomposites.…”

Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements

“…Calcium phosphate materials have been increasingly employed in orthopedic and dental applications. Recently, much attention has been paid to calcium phosphate cements (CPCs) because of their advantages in comparison with calcium phosphate bioceramics, regarding in situ handling and shaping abilities [ 1 , 2 ]. The CPCs are obtained by an acid-base reaction in water between an acidic calcium phosphate and a basic calcium phosphate, giving an intermediate basicity calcium phosphate that precipitates [ 3 ].…”