Synthesis of Bisindolylmethanes and Their Cytotoxicity Properties

Abstract

Polymer supported dichlorophosphate (PEG-OPOCl2) is an efficient green catalyst for the electrophilic substitution reaction of indole with aromatic aldehydes, in neat condition, to afford an excellent yield of bis(indolyl) methanes with short reaction time, at room temperature. The synthesized compounds and their anti-cancer activity are evaluated.

Synthesis of Bis(indolyl)methanes Using Hyper-Cross-Linked Polyaromatic Spheres Decorated with Bromomethyl Groups as Efficient and Recyclable Catalysts

“…In the 13 C NMR spectra of the products, the Ar–CH carbon signals were observed in the region of 54.1–32.2 ppm, confirming the formation of BIMs (Supporting Information). 37…”

Efficient, Solvent-Free, Multicomponent Method for Organic-Base-Catalyzed Synthesis of β-Phosphonomalonates

“…We are interested in the development of various organic transformations under solvent-free conditions [20][21][22] and in exploring the catalytic properties of DBA in two different organic transformations. 15, 19 We found that DBA is a useful precursor for selective chemical transformations.…”

Fe3O4@SiO2 supported aza-crown ether complex cation ionic liquids: preparation and applications in organic reactions

“…Particularly bisindolylmethanes (BIMs) are widely existed in various natural products and exhibit a wide range of biological activities including anticancer activity against several cancer cell lines. 25,26 Bisindolylmethanes have been commonly prepared by reactions of indoles with various aldehydes or ketones in the presence of either Brønsted or Lewis acids. [27][28][29] Herein, the supported aza-crown ether complex cation ionic liquid containing [HSO 4 À ] was applied to the Friedel-Cras alkylation reaction as a good heterogenous catalyst.…”