Synthesis of 2-azetidinones substituted quinoline derivative

Mashelkar, C Uday; Jha, Satadru; Mashelkar, U Beena

doi:10.2298/jsc120617081m

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…One-pot three-component reactions were performed between salicylaldehyde, α-ketoester and various aromatic aldehydes (Scheme 15) [46,47]. Several reactions were performed in order to optimize reaction conditions changing catalyst (FeCl 3 ‧6H 2 O, Fe(OTf) 3 , ZnBr 2 , Zn(OTf) 2 , MgCl 2 , Mg(OTf) 2 , CuCl 2 , Cu(OTf) 2 and Bi(OTf) 3 ) and solvent (MeOH, N, N-dimethyl formamide, toluene, MeCN and DCM).…”

Section: One Pot Reactionmentioning

confidence: 99%

Coumarin: A Valid Scaffold in Medicinal Chemistry

Surana¹,

Mahajan²,

Patil³

2021

JASR

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The coumarin scaffold is an important structure in medicinal chemistry because it is found in several naturally occurring molecules which exhibit a variety of biological activities, such as anti-cancer, anti-inflammatory, anti-diabetic, antimicrobial, and antiviral, antifungal. In addition, various synthetic coumarins motifs are present in marketed drugs. They are also involved in the actions of the photosynthesis, control of respiration, plant growth hormones and growth regulators, and also defense against infection. This review will provide an overview of coumarin moieties with medicinal aspects synthesized in the last 15 years and will cover the most potent molecule in each report. In this review, different synthesis methods of coumarin and their derivatives have been covered.

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Section: One Pot Reactionmentioning

confidence: 99%

Coumarin: A Valid Scaffold in Medicinal Chemistry

Surana¹,

Mahajan²,

Patil³

2021

JASR

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Chemistry and Pharmacology of Acetanilide Derivatives: A Mini Review

Singh

Kumar

Mishra

2018

LOC

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Acetanilide or N-phenylacetamide is an aromatic compound having phenyl ring attached to an acetamido group (–NHCOCH3). In 1886, acetanilide was introduced as an analgesic and antipyretic drug into medical practice by A. Cahn and P. Hepp. Since then, many acetanilide derivatives have been found to have antimicrobial, analgesic, anti-inflammatory, antipyretic, antioxidant, anticonvulsant, anti- cancer, antihyperglycaemic and antimalarial activities. Acetanilide also plays an important role in the synthesis of a number of chemicals as intermediates and precursors. The chief objective of the present article is to highlight the chemistry and pharmacological aspects of various derivatives of acetanilide and their pharmacological activities to assist the future discovery of more efficacious derivatives with less toxicity.

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Synthesis of 2-azetidinones substituted quinoline derivative

Cited by 2 publications

References 8 publications

Coumarin: A Valid Scaffold in Medicinal Chemistry

Coumarin: A Valid Scaffold in Medicinal Chemistry

Chemistry and Pharmacology of Acetanilide Derivatives: A Mini Review

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