Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity

Abstract

Anticancer screening of several 1,2,3-triazoles with heterocyclic fragments has been performed. The 1,2,3-triazole derivatives were synthesized from available starting materials according to convenient synthetic procedures. The antitumor activity of the synthesized compounds was tested in vitro by the National Cancer Institute in NCI60 cell lines. It was observed that some compounds showed slight anticancer activity. One of them possessed a moderate activity against melanoma, colon, and breast cancer. Standard COMPARE analysis was performed at the GI50 level.

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

“…7, exerts variable cytotoxic effects against the different cell lines with IC 50 of 40.0 AE 14.6 mM. This different behavior could be due to the introduction of triazolium salts onto the carrier, that it is known to possess very interesting biological activities, in particular antitumoral effect (Pokhodylo et al, 2013).…”

Reactions of Malonothioamide Derivatives with Azides*

“…The 1,2,3-triazole ring forms the structural basis of antibacterial, anti-inflammatory, and hypotensive medications, neuroleptics, antiHIV agents, and pesticides [1,2]. Selective inhibitors of HIV-1 protease and histone deacetylase, which are prospective antitumor agents, have been found among the derivatives of 1,2,3-triazole [10][11][12][13][14]. A broad spectrum of biological activity is also characteristic of 1,2,3-thiadiazole derivatives.…”

Crystal structure of 2-((3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)-1H-indene-1,3(2H)-dione, C28H19N5O2

“…1,2,3-Triazoles [2][3][4][5][6] are known for their biological applications such as antidiabetic, anti-in ammatory, antifungal, antiviral and antibacterial activity [7][8][9]. In the title crystal structure, the asymmetric unit consists of one molecule of C 28 H 19 N5O 2 .…”