Synthesis, molecular docking simulation, and biological evaluation studies of novel amide and ether conjugates of 2,3‐diaryl‐1,3‐thiazolidin‐4‐ones

Daipule, Komal; Goud, Nerella Sridhar; Sethi, Aaftaab; Gurrapu, Swapna; Mamidala, Estari; Alvala, Mallika

doi:10.1002/jhet.3819

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…It demonstrated that compound 31 exhibited hydrogen bond interaction of C=O with Lys103, Lys101, and pi‐pi stacking of aromatic group with Trp229. Taking nevirapine as a reference medicine against HIV‐1 RT, substitution at meta position resulted in a potency drop [85] …”

Section: Role Of Nitrogen‐containing Heterocyclic Compounds In Inhibi...mentioning

confidence: 99%

“…Taking nevirapine as a reference medicine against HIV-1 RT, substitution at meta position resulted in a potency drop. [85] Suryawanshi and teammates created novel 4-thiazolidinone-based compounds and investigated their anti-HIV-1 activity using in-silico and in-vitro study methods. The lead compound showed maximum inhibition activity in TZM-bl assay and PBMC assay using NIH ARRRP reference strain.…”

Section: Thiazolidinone-based Rt Inhibitorsmentioning

confidence: 99%

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Recent Advances on the Role of Nitrogen‐Based Heterocyclic Scaffolds in Targeting HIV through Reverse Transcriptase Inhibition

Kumar¹,

Wahan²,

Virendra³

et al. 2022

ChemistrySelect

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Acquired immune deficiency syndrome (AIDS) caused by human immunodeficiency virus continues to scavenge lives of millions around the world. Reverse transcriptase (RT) also known as the RNA-directed DNA polymerase enzyme is responsible for converting RNA into viral DNA through process known as reverse transcription. Investigations on the pathogenic aspects of the RT enzyme, its associated elements such as gag (group-specific antigen gene), pol (polymerase gene), and env (environmental gene) (envelope gene) reveals its contribution towards emergence of resistance to all various anti-HIV drugs. Therefore, research into the control and blockage of the RT pathway has been a prominent focus in the quest for novel targets for HIV treatment. A slew of heterocyclics has been claimed to play a significant part in the fight against doomy HIV, saving the lives of millions of people throughout the world and providing hope for HIV treatment. Due to their improved potency and selectivity, as well as the fact that they have fewer off-target effects against the several targets implicated in RT inhibition, heterocyclics are becoming more and more useful. The RT inhibition pathway, the function of numerous heterocyclic scaffolds, and their ability to inhibit the RT enzyme pathway have all been the main topics of this paper. Recent advances in RT inhibitors in the last eight years (2014-2022) including mechanisms of action, preclinical and clinical investigations, structural activity relationships, and docking studies, to investigate mechanistic studies that would eventually aid in the design and development of powerful RT inhibitors have also discussed.

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Section: Role Of Nitrogen‐containing Heterocyclic Compounds In Inhibi...mentioning

confidence: 99%

Section: Thiazolidinone-based Rt Inhibitorsmentioning

confidence: 99%

Recent Advances on the Role of Nitrogen‐Based Heterocyclic Scaffolds in Targeting HIV through Reverse Transcriptase Inhibition

Kumar¹,

Wahan²,

Virendra³

et al. 2022

ChemistrySelect

View full text Add to dashboard Cite

show abstract

Novel benzimidazole-triazole hybrids as apoptosis inducing agents in lung cancer: Design, synthesis, 18F-radiolabeling & galectin-1 inhibition studies

Goud

Pooladanda

Chandra

et al. 2020

Bioorganic Chemistry

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Synthesis and biological evaluation of novel 4,7-disubstituted coumarins as selective tumor-associated carbonic anhydrase IX and XII inhibitors

Chandra

Goud

Arifuddin

et al. 2021

Bioorganic & Medicinal Chemistry Letters

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Synthesis, molecular docking simulation, and biological evaluation studies of novel amide and ether conjugates of 2,3‐diaryl‐1,3‐thiazolidin‐4‐ones

Cited by 4 publications

References 17 publications

Recent Advances on the Role of Nitrogen‐Based Heterocyclic Scaffolds in Targeting HIV through Reverse Transcriptase Inhibition

Recent Advances on the Role of Nitrogen‐Based Heterocyclic Scaffolds in Targeting HIV through Reverse Transcriptase Inhibition

Novel benzimidazole-triazole hybrids as apoptosis inducing agents in lung cancer: Design, synthesis, 18F-radiolabeling & galectin-1 inhibition studies

Synthesis and biological evaluation of novel 4,7-disubstituted coumarins as selective tumor-associated carbonic anhydrase IX and XII inhibitors

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