Synthesis, Magnetic, Spectral and Biological Studies of Copper(II) Complexes of 4-Benzoyl-3-Methyl-1-Phenyl-2-Pyrazolin-5-One N(4)-Substituted Thiosemicarbazones

Abstract

Abstract:The synthesis and characterization of copper(II) complexes with 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one thiosemicarbazone and N(4)-substituted thiosemicarbazones are reported. Elemental analysis, molar conductivities, magnetic measurements and spectral (i.r., electronic, e.s.r., and n.m.r.) studies have been used to characterize the complexes. The i.r. spectra show that the thiosemicarbazones behave as bidentate ligands, either in the thione or thiolato form. Stereochemistries are proposed for the complexes on the basis of spectral and magnetic studies. Both the thiosemicarbazones and their complexes show either modest or no growth inhibitory activity against Aspergillus niger and Paecilomyces variotii.

Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells

“…The room-temperature magnetic moments (μ eff BM per metal atom) and electronic spectral bands for the metal complexes in the solid state are described in Table 3. The data showed that the electronic absorption spectrum of ligand 1 exhibits bands at 268 and 280 nm, attributable to intra-ligand π→π* electronic transitions [15,30]. These bands do not change significantly upon complex formation [31].…”

Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells

“…The room-temperature magnetic moments (μ eff BM per metal atom) and electronic spectral bands for the metal complexes in the solid state are described in Table 3. The data showed that the electronic absorption spectrum of ligand 1 exhibits bands at 268 and 280 nm, attributable to intra-ligand π→π* electronic transitions [15,30]. These bands do not change significantly upon complex formation [31].…”

Synthesis, Cytotoxicity and Molecular Docking Study of Complexes Containing Thiazole Moiety

“…The applications of metal complexes of dyes not limited for industries but also in the field of pharmacology such as inhibition of DNA, RNA, and protein synthesis, nitrogen fixation, and carcinogenesis (24,25). 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one is the biological potent organic moiety (26,27). Many researchers work on metal chelate of 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (28)(29)(30)(31)(32) but the catalytic synthesis of dyes from this organic moiety is not reported.…”

Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells

“…The room-temperature magnetic moments (μ eff BM per metal atom) and electronic spectral bands for the metal complexes in the solid state are described in Table 3. The data showed that the electronic absorption spectrum of ligand 1 exhibits bands at 268 and 280 nm, attributable to intra-ligand π→π* electronic transitions [15,30]. These bands do not change significantly upon complex formation [31].…”

Synthesis, Cytotoxicity and Molecular Docking Study of Complexes Containing Thiazole Moiety

“…The applications of metal complexes of dyes not limited for industries but also in the field of pharmacology such as inhibition of DNA, RNA, and protein synthesis, nitrogen fixation, and carcinogenesis (24,25). 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one is the biological potent organic moiety (26,27). Many researchers work on metal chelate of 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (28)(29)(30)(31)(32) but the catalytic synthesis of dyes from this organic moiety is not reported.…”

Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells

“…The room-temperature magnetic moments (μ eff BM per metal atom) and electronic spectral bands for the metal complexes in the solid state are described in Table 3. The data showed that the electronic absorption spectrum of ligand 1 exhibits bands at 268 and 280 nm, attributable to intra-ligand π→π* electronic transitions [15,30]. These bands do not change significantly upon complex formation [31].…”

Synthesis, Cytotoxicity and Molecular Docking Study of Complexes Containing Thiazole Moiety

“…The applications of metal complexes of dyes not limited for industries but also in the field of pharmacology such as inhibition of DNA, RNA, and protein synthesis, nitrogen fixation, and carcinogenesis (24,25). 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one is the biological potent organic moiety (26,27). Many researchers work on metal chelate of 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (28)(29)(30)(31)(32) but the catalytic synthesis of dyes from this organic moiety is not reported.…”