Synthesis, in silico study, and biological evaluation of cyclosulfamide derivatives as new anticholinesterase inhibitors

BiCl3-catalyzed green synthesis of 4-hydroxy-2-quinolone analogues under microwave irradiation

“…Many natural and synthetic active products bear a heterocycle within their structures; these molecules are recognized for their vast number of applications in the medical eld, exhibiting various benecial pharmacological activities. [12][13][14][15][16][17][18][19][20] A well-known class of heterocycles, 4-hydroxyquinolin-2-one and its tautomers (Scheme 1), 21 are of great interest in both chemical and medicinal domains. In 2017, the number of described molecules containing a 4-hydroxyquinolin-2-one skeleton reached 14 thousand including nearly 7 thousand compounds that had been subjected to bioactivity studies.…”