Synthesis, Identification and Biological Activity of Some New Chalcone derivatives from 8-Chlorotheophylline

Abstract

New derivatives of 8-Chloro-theophylline (8-CTh) were synthesized by react 8-CTh and 4-amino acetophenone to prepared 8-(4-acetylphenylamino)-1,3-dimethyl-1H-purine-2,6(3H,7H)dione then the result reacts with some substituted benzaldehyde derivatives to prepared different chalcone compound then the products were allowed to react with thiourea and hydrazine to give Pyrimidine and pyrazoline derivatives respectively. The reaction was monitored by thin layer chromatography (TLC) technique. All new compounds were characterized by melting points, elemental analysis, FTIR, 1 H, 13 C and 2D NMR spectroscopy. Antimicrobial activity of these derivatives was also determined.

Enamines and Dimethylamino Imines as Building Blocks in Heterocyclic Synthesis: Reactions of DMF‐DMA Reagent with Different Functional Groups

“…Amino groups that act as nucleophiles attack the partially positive carbon atom of the DMF‐DMA reagent to give the imine group. The reaction mechanism of this reaction is similar to the addition of amino group into carbonyl groups [17] . This type of reaction usually takes place in reflux condition and yield of the reaction is high.…”

Enamines and Dimethylamino Imines as Building Blocks in Heterocyclic Synthesis: Reactions of DMF‐DMA Reagent with Different Functional Groups

“…Amino groups that act as nucleophiles attack the partially positive carbon atom of the DMF‐DMA reagent to give the imine group. The reaction mechanism of this reaction is similar to the addition of amino group into carbonyl groups [17] . This type of reaction usually takes place in reflux condition and yield of the reaction is high.…”

New Chalcone Derivatives as Anticancer and Antioxidant Agents: Synthesis, Molecular Docking Study and Biological Evaluation

“…Fourier-transform infrared (FT-IR) spectra were recorded with FT-IR spectrophotometer (Bruker). Nuclear magnetic resonance (NMR) measurements ( 1 H NMR, 13 C NMR) were measured on Bruker AMX 400 and 100 instruments using CHEMICAL PROBLEMS 2024 no. 2 (22) tetramethylsilane (TMS) as a reference and DMSO-d 6 as a solvent.…”

“…In the next step, the derivative 3 was reacted with some aromatic aldehydes 4a-d in the presence of piperidine as a catalyst to synthesize chalcone derivatives 5a-d according to the Claisen-Schmidt condensation mechanism, as shown in Scheme 2. The structures of all synthesized compounds were spectroscopically characterized by (IR, 1 H NMR, 13 C NMR) as well as micro-elements analysis. The spectroscopic data obtained were included in the Experimental part.…”

“…İşdə, tərkibində baklofen preparatı olan bir sıra yeni xalkon törəmələri Claisen-Schmidt kondensasiyası ilə sintez edilmiş, xərçəng əleyhinə və antioksidant agentlər kimi in vitro qiymətləndirilmişdir. Yeni sintez edilmiş birləşmələr FT-İK, 1 H-NMR,13 C-NMR spektrləri ilə xarakterizə edilmişdir və həmçinin element analizi aparılmışdır. Bütün alınan maddələr həm HdFn, həm də MCF-7 hüceyrələrə qarşı in vitro olaraq yoxlanılmışdır.…”

“…CHEMICAL PROBLEMS 2024 no. 2 (22) охарактеризованы спектрами ИК-Фурье, 1 Н-ЯМР, 13 С-ЯМР и элементным анализом. Все продукты были проверены in vitro на клеточные линии HdFn и MCF-7.…”

Enamines and Dimethylamino Imines as Building Blocks in Heterocyclic Synthesis: Reactions of DMF‐DMA Reagent with Different Functional Groups

“…Amino groups that act as nucleophiles attack the partially positive carbon atom of the DMF‐DMA reagent to give the imine group. The reaction mechanism of this reaction is similar to the addition of amino group into carbonyl groups [17] . This type of reaction usually takes place in reflux condition and yield of the reaction is high.…”

New Chalcone Derivatives as Anticancer and Antioxidant Agents: Synthesis, Molecular Docking Study and Biological Evaluation

“…Fourier-transform infrared (FT-IR) spectra were recorded with FT-IR spectrophotometer (Bruker). Nuclear magnetic resonance (NMR) measurements ( 1 H NMR, 13 C NMR) were measured on Bruker AMX 400 and 100 instruments using CHEMICAL PROBLEMS 2024 no. 2 (22) tetramethylsilane (TMS) as a reference and DMSO-d 6 as a solvent.…”

“…In the next step, the derivative 3 was reacted with some aromatic aldehydes 4a-d in the presence of piperidine as a catalyst to synthesize chalcone derivatives 5a-d according to the Claisen-Schmidt condensation mechanism, as shown in Scheme 2. The structures of all synthesized compounds were spectroscopically characterized by (IR, 1 H NMR, 13 C NMR) as well as micro-elements analysis. The spectroscopic data obtained were included in the Experimental part.…”

“…İşdə, tərkibində baklofen preparatı olan bir sıra yeni xalkon törəmələri Claisen-Schmidt kondensasiyası ilə sintez edilmiş, xərçəng əleyhinə və antioksidant agentlər kimi in vitro qiymətləndirilmişdir. Yeni sintez edilmiş birləşmələr FT-İK, 1 H-NMR,13 C-NMR spektrləri ilə xarakterizə edilmişdir və həmçinin element analizi aparılmışdır. Bütün alınan maddələr həm HdFn, həm də MCF-7 hüceyrələrə qarşı in vitro olaraq yoxlanılmışdır.…”

“…CHEMICAL PROBLEMS 2024 no. 2 (22) охарактеризованы спектрами ИК-Фурье, 1 Н-ЯМР, 13 С-ЯМР и элементным анализом. Все продукты были проверены in vitro на клеточные линии HdFn и MCF-7.…”

Enamines and Dimethylamino Imines as Building Blocks in Heterocyclic Synthesis: Reactions of DMF‐DMA Reagent with Different Functional Groups

“…Amino groups that act as nucleophiles attack the partially positive carbon atom of the DMF‐DMA reagent to give the imine group. The reaction mechanism of this reaction is similar to the addition of amino group into carbonyl groups [17] . This type of reaction usually takes place in reflux condition and yield of the reaction is high.…”

New Chalcone Derivatives as Anticancer and Antioxidant Agents: Synthesis, Molecular Docking Study and Biological Evaluation

“…Fourier-transform infrared (FT-IR) spectra were recorded with FT-IR spectrophotometer (Bruker). Nuclear magnetic resonance (NMR) measurements ( 1 H NMR, 13 C NMR) were measured on Bruker AMX 400 and 100 instruments using CHEMICAL PROBLEMS 2024 no. 2 (22) tetramethylsilane (TMS) as a reference and DMSO-d 6 as a solvent.…”

“…In the next step, the derivative 3 was reacted with some aromatic aldehydes 4a-d in the presence of piperidine as a catalyst to synthesize chalcone derivatives 5a-d according to the Claisen-Schmidt condensation mechanism, as shown in Scheme 2. The structures of all synthesized compounds were spectroscopically characterized by (IR, 1 H NMR, 13 C NMR) as well as micro-elements analysis. The spectroscopic data obtained were included in the Experimental part.…”

“…İşdə, tərkibində baklofen preparatı olan bir sıra yeni xalkon törəmələri Claisen-Schmidt kondensasiyası ilə sintez edilmiş, xərçəng əleyhinə və antioksidant agentlər kimi in vitro qiymətləndirilmişdir. Yeni sintez edilmiş birləşmələr FT-İK, 1 H-NMR,13 C-NMR spektrləri ilə xarakterizə edilmişdir və həmçinin element analizi aparılmışdır. Bütün alınan maddələr həm HdFn, həm də MCF-7 hüceyrələrə qarşı in vitro olaraq yoxlanılmışdır.…”

“…CHEMICAL PROBLEMS 2024 no. 2 (22) охарактеризованы спектрами ИК-Фурье, 1 Н-ЯМР, 13 С-ЯМР и элементным анализом. Все продукты были проверены in vitro на клеточные линии HdFn и MCF-7.…”