Synthesis, DNA-binding, and Antiviral Activity of Certain Pyrazolo[3,4-d]pyrimidine Derivatives

Synthesis and Antiviral Activity of New Indole-Based Heterocycles

“…[20][21][22] Aphidicolin was used as a positive control. From the results obtained in Table 1, we can conclude that, compounds 1,2,4-triazole-5(4H)-thione 4, 2-thioxothiazole 6, thiazoles 8a, b and thiazolidin-4-one 13 showed no antiviral activity.…”

Crystal structure of N,N-dimethyl-N′-(2-methyl-4-oxo-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)formimidamide, C14H18N4OS

“…Pyrimidine nucleus has gained potential importance in medicinal chemistry, as some of its derivatives exhibited a wide range of biological activities, such as antiviral [5][6][7][8], anticoccidials [9,10], antimicrobial [11][12][13][14], antitumor [15][16][17][18], herbicidal, antileukemic [19,20], pesticides [21], CNS agents [22], tuberculostatic [23][24][25], antileishmanial [26][27][28], radioprotectant [29], anti-in ammatory [30], and cardiovascular activities [31,32]. The biological signicance of the above heterocycle prompted us to explore the synthesis of novel pyrimidines from 3-amino-2-methyl-5,6, 7,8-tetrahydrobenzo [4,5] The asymmetric unit of the title compound contains one independent molecule. The bond lengths of N1-C10 and N3-C12 are 1.300(5) and 1.282(5) Å, respectively, which are typical C = N double bonds and the con guration around these double bonds are trans.…”

Design and Synthesis of Peptide Derivatives Act as DNA Binding Agent and Discovery of Potent Carbonic Anhydrase Inhibitors Using Docking Studies

“…All the products (3)(4)(5) were chromatographically homogeneous by iodine and benzidine development. (6)(7)(8) General procedures To a suspension of coupling reaction products (3-5; 1 equiv) in absolute methanol (150 ml) was cooled to -10°C and pure thionyl chlorid (1 equiv) was added dropwise during one hour. The reaction mixture was stirred for an additional 34 hr at room temperature, then kept overnight then the solvent was removed by vacuum distillation.…”

“…The structural changes of DNA based on the interaction of small molecular weight ligands with DNA have attracted attention in the medicinal design of anticancer and anti-AIDS drugs (6,7) . Some chromen-2-one (coumarine) derivatives have been reported to possess anti-SARS agent (8) , antioxidant properties (9) , anti-fungal (10) , anti-bacterial (11) , antiinflammatory (12) , antitumor (13) , inhibitors of pancreatic cholesterol (14) , estrogen receptor (15) and treatment of Alzheimer diseases (16) .…”