Synthesis, cytotoxic activity on MCF-7 cell line and mutagenic activity of platinum(II) complexes with 2-substituted benzimidazole ligands

Gümüş, Fatma; Algül, Öztekin; Eren, Gökçen; Eroğlu, Hatice; Dırıl, Nuran; Gür, Sibel

doi:10.1016/s0223-5234(03)00058-8

Cited by 74 publications

(26 citation statements)

References 37 publications

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“…It has been found that such complexes show greater anti-microbial activities than the free ligands. [12,13] However, their interaction with biological systems requires appropriate selection of metals. Silver salts have a longstanding history as important therapeutic agents for maintaining human health.…”

Section: Introductionmentioning

confidence: 99%

Benzimidazole‐based silver(I)–N‐heterocyclic carbene complexes as anti‐bacterials: synthesis, crystal structures and nucleic acids interaction studies

Asekunowo

Haque

Razali

et al. 2014

Applied Organom Chemis

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A series of new benzimidazolium salts as N-heterocyclic carbene (NHC) precursors has been synthesized. Reactions of these salts with Ag 2 O with varying metal-to-salt ratio facilitate the formation of a series of new binuclear and mononuclear Ag(I)-NHC complexes. All compounds were characterized using physicochemical and spectroscopic techniques. Single-crystal X-ray diffraction study reveals a binuclear structure for one of the complexes and a mononuclear one for two others. These complexes exist as cationic Ag(I)-NHC complexes with the chelation of carbene carbons to the silver centre in an almost linear manner. The compounds were screened for their anti-bacterial activities against Staphylococcus aureus (ATCC 12600) as a Gram-positive bacterium and Escherichia coli (ATCC 25922) as a Gram-negative bacterium. The results show that both bacteria appear markedly inhibited. Furthermore, the results suggest the possibility of steric variation as a modulation of the anti-bacterial activities. The nuclease activities of the compounds were assessed using gel electrophoresis and the results indicate that these complexes can cleave or degrade DNA and RNA via a non-oxidative mechanism.

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Section: Introductionmentioning

confidence: 99%

Benzimidazole‐based silver(I)–N‐heterocyclic carbene complexes as anti‐bacterials: synthesis, crystal structures and nucleic acids interaction studies

Asekunowo

Haque

Razali

et al. 2014

Applied Organom Chemis

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“…Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands activity and toxicity of platinum complexes and with the aim of determining the role of the substituents on position 2 of the benzimidazole carrier ligands of platinum(II) complexes on cytotoxic properties, we synthesized some platinum(II) complexes with 2-substituted benzimidazole ligands [8][9][10][11][12][13][14][15][16] . It was determined that some of these platinum complexes have in vitro cytotoxic activities on RD 9 , HeLa 12,[14][15][16] , MCF-7 10,12,[14][15][16] , and HEp-2 16 cell lines.…”

Section: Research Articlementioning

confidence: 99%

“…It was determined that some of these platinum complexes have in vitro cytotoxic activities on RD 9 , HeLa 12,[14][15][16] , MCF-7 10,12,[14][15][16] , and HEp-2 16 cell lines. In the present study, as an extension of the investigation on the probable anticancer activity of platinum complexes with 2-substituted benzimidazole ligands, four Pt(II) complexes with bulky, near-planar, hydrophobic amine ligands, including 2-ethyl (1), benzyl (2), p-chlorobenzyl (3), and phenoxymethyl (4) benzimidazoles, were evaluated for their in vitro cytotoxic activities against the human HeLa cervix, oestrogen receptorpositive MCF-7 breast, and oestrogen receptor-negative MDA-MB 231 breast cancer cell lines.…”

Section: Research Articlementioning

confidence: 99%

Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands

Özçelik

Utku

Gümüş

et al. 2012

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…All cells were cultured in flasks at 37°C in the 100%-humidity atmosphere and 5% of CO 2 (25). Only viable cells were used in the assay.…”

Section: Mtt Assaymentioning

confidence: 99%

Synthesis, characterization, antiamoebic activity and cytotoxicity of new pyrazolo[3, 4-d]pyrimidine-6-one derivatives

Hayat

Salahuddin

Azam

2010

Journal of Enzyme Inhibition and Medicinal Chemistry

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Synthesis, cytotoxic activity on MCF-7 cell line and mutagenic activity of platinum(II) complexes with 2-substituted benzimidazole ligands

Cited by 74 publications

References 37 publications

Benzimidazole‐based silver(I)–N‐heterocyclic carbene complexes as anti‐bacterials: synthesis, crystal structures and nucleic acids interaction studies

Benzimidazole‐based silver(I)–N‐heterocyclic carbene complexes as anti‐bacterials: synthesis, crystal structures and nucleic acids interaction studies

Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands

Synthesis, characterization, antiamoebic activity and cytotoxicity of new pyrazolo[3, 4-d]pyrimidine-6-one derivatives

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