volume 6, issue 57, P51520-51532 2016
DOI: 10.1039/c6ra09387f
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Abstract: The formation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for its antitumor activity but they also make these drugs cardiotoxic. When complexed with metal ions there is a decrease in ROS formation and therefore in cardiotoxicity. Interestingly, inspite of producing fewer ROS, some of the complexes are effective antitumor agents, often better than the parent anthracycline. Purpurin (LH 3 ), a hydroxy-9, 10-anthraquinone, resembles doxorubicin at the core. An Mn II complex of…

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