Synthesis, characterization, structure, in vitro enzymatic activity and sensing aspects of a copper(II) complex stabilized from a naphthaldehyde based Schiff base ligand

“…This evidences C N bond formation. 26 Upon complexation, this band shifted bathochromically to lower wavenumber values of 1632 and 1645 cm À1 for 1 and 2, respectively. This owes to the coordination of azomethine N of free ligand to copper(II) centres.…”

Section: Synthesis and Characterizationmentioning

confidence: 98%

Synthesis, characterization, crystal structure, thermal and redox behaviour and antiproliferative studies of morpholine‐based two copper(II) compounds

Mandal

Nandi

Acharya

et al. 2023

Applied Organom Chemis

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Two novel copper(II) complexes, [Cu(L)(Cl) 2 ](H 2 O) (1) and [Cu(L)(N 3 ) 2 ] (2), have been synthesized from a morpholine-based N,N,N donor tridentate Schiff base ligand, (E)-N-(2-morpholinoethyl)-1-phenyl-1-(pyridin-2-yl)methanimine (L). Ligand (L) and its stabilized complexes, 1 and 2, have been comprehensively characterized by different physical and spectroscopic techniques. Solidstate single-crystal X-ray structures of both 1 and 2 have been determined. Powder X-ray diffraction studies on the bulk samples of 1 and 2 have been executed to demonstrate that the synthesized bulk materials retain their solidphase purity as that exists in the single crystals. Cyclic voltammetric experiments have been done to demonstrate the redox behaviour of 1 and 2. UV-vis spectra of the copper(II) complexes with variation in time were accrued to probe that both 1 and 2 retain their stability in solution. Thermogravimetric analysis (TGA) has been performed to collate the thermal stability of 1 along with its possible thermal degradation behaviour. Room temperature magnetic moments of 1 and 2 have been determined. Cytotoxic activity of 1 and 2 has been screened against non-small human lung cancer cell, A549.

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“…At 10 À3 M concentration, the percentage of inhibition towards the said enzymes were respectively found to be 51.29 AE 1.32, 17.07 AE 1.23 and 63.52 AE 2.19. 18 Recently, a triazole based tridentate Schiff base ligand has been screened for a-amylase inhibition. The result of this inhibition has been reported with an IC 50 value of 2.51 AE 0.02 mmol mL À1 .…”

Section: Enzyme Activitymentioning

confidence: 99%

“…17 Of late, a naphthaldehyde based Schiff base moiety has been demonstrated to function as a trypsin inhibitor. 18 Obesity is a common type of physiological disorder. It involves excess accumulation of fat.…”

Section: Introductionmentioning

confidence: 99%

“…angle (1) N(1)-N(2)-C(18) 118.0(16) N(5)-N(6)-C(38) 114.6(17) 114.55 936 C(1)-N(1)-N(2) 115.7(17) C(21)-N(5)-N(6) 115.2(17) 115.23 967 C(2)-C(1)-N(1) 117.7(19) C(22)-C(21)-N(5) 121(2) 120.66 447 N(2)-C(18)-N(3) 119.8(18) N(6)-C(38)-N(8) 123(2) 122.83 602 N(2)-C(18)-N(4) 123(2) N(6)-C(38)-N(7) 127(2) 126.59 620 C(1)-C(2)-C(17) 119.3(19) C(21)-C(22)-C(23) 121(2) 121.43 342 appreciable inhibition of trypsin. Even at very low concentrations (10 À8 M), PI manifested significant inhibition of 46.5%.…”

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confidence: 99%

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Design, synthesis, crystal structure, photophysical behavior and aggregation-induced emission of a novel pyrene scaffold multifunctional Schiff base ligand: inhibition of digestive enzymes and docking studies

et al. 2023

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Synthesis, characterization, structure, in vitro enzymatic activity and sensing aspects of a copper(II) complex stabilized from a naphthaldehyde based Schiff base ligand

Cited by 6 publications

References 65 publications

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu₃OH core with regard to aspects of antiproliferative activity and magnetic properties

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu₃OH core with regard to aspects of antiproliferative activity and magnetic properties

Synthesis, characterization, crystal structure, thermal and redox behaviour and antiproliferative studies of morpholine‐based two copper(II) compounds

Design, synthesis, crystal structure, photophysical behavior and aggregation-induced emission of a novel pyrene scaffold multifunctional Schiff base ligand: inhibition of digestive enzymes and docking studies

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Synthesis, characterization, structure, in vitro enzymatic activity and sensing aspects of a copper(II) complex stabilized from a naphthaldehyde based Schiff base ligand

Cited by 6 publications

References 65 publications

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu3OH core with regard to aspects of antiproliferative activity and magnetic properties

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu3OH core with regard to aspects of antiproliferative activity and magnetic properties

Synthesis, characterization, crystal structure, thermal and redox behaviour and antiproliferative studies of morpholine‐based two copper(II) compounds

Design, synthesis, crystal structure, photophysical behavior and aggregation-induced emission of a novel pyrene scaffold multifunctional Schiff base ligand: inhibition of digestive enzymes and docking studies

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Product

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Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu₃OH core with regard to aspects of antiproliferative activity and magnetic properties

Design, synthesis and structure of a trinuclear copper(ii) complex having a Cu₃OH core with regard to aspects of antiproliferative activity and magnetic properties