Synthesis, characterization, single crystal XRD, in vitro antimicrobial and cytotoxicity study of tris(ethylenediamine)cobalt(III)chloride oxalate trihydrate

Abstract

The complex tris(ethylenediamine)cobalt(III)chloride oxalate trihydrate [Co(en) 3 ] Cl(C 2 O 4 )AE3H 2 O crystallizes in the monoclinic space group C 2 /c with the following unit cell parameters a = 19.9318 (13), b = 9.3344 (4), c = 19.0881 (13) Å b = 96.846(3)°, Z = 8. The crystal structure was solved by direct methods and refined by full matrix least squares procedures to a final R value of 0.0314 for 4330 observed reflections. The reported cobalt complex is six co-ordinated through amine nitrogen with distorted octahedral geometry. There are uncoordinated chloride and oxalate ions along with the water molecules. In-vitro antimicrobial activity was studied against various test organisms and found to be good. From in-vitro cytotoxic activity of the synthesized complex, the IC 50 value was found to be 55.85 lg/ml. ª 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

Anti-Dengue Type 2 Virus Activities of Zinc (Ii) Complex Compounds With 2-(2,4 -Dihydroxyphenyl)-3,5,7-Trihydroxycromen-4-One Ligands in Vero Cells

“…The bulky 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxycromen -4-one ligand on binding to the metal cation reduces the polarity of the metal ion due to the ligand orbital overlap with the metal orbitals, resulting in a delocalization of positive charge. 16 This increases the lipophilic character of the metal favors its permeation through the lipoid layer of the virus membranes. 17 The effects of other compounds against cellular RNA polymerases and formation of the complex with RNA have reported suggesting that compound could also affect the similar replication enzymes.…”