Synthesis, characterization of ZnO-chitosan nanocomposites and evaluation of its antifungal activity against pathogenic Candida albicans

Comparison of antifungal and cytotoxicity activities of titanium dioxide and zinc oxide nanoparticles with amphotericin B against different Candida species: In vitro evaluation

“…Dananjaya et al concluded that significant changes occurred in the external morphology of C albicans after treatment with both types of ZnO‐NPs due to the damage to the fungal cell membrane. In addition, the cytotoxicity of both nanoparticles was compatible with the increase in the concentration of Hep2 cells and C albicans 24 . In another study, chemically synthesized TiO2‐NPs exhibited higher anti‐candidal property compared with FLC 25…”

“…25 In the present study, the inhibitory effect of the ZnO-NPs occurred at MIC = 128 μg/mL for C albican, while MIC of ZnO-NPs and ZnO-chitosan nanocomposites on C albican was 200 μg/mL and 75 μg/mL, respectively. 24 In the study concluded by Grabchev et al,…”

“…In addition, the cytotoxicity of both nanoparticles was compatible with the increase in the concentration of Hep2 cells and C albicans. 24 In another study, chemically synthesized TiO2-NPs exhibited higher anti-candidal property compared with FLC. 25 In the present study, the inhibitory effect of the ZnO-NPs occurred at MIC = 128 μg/mL for C albican, while MIC of ZnO-NPs and ZnO-chitosan nanocomposites on C albican was 200 μg/mL and 75 μg/mL, respectively.…”

Microwave-Assisted Green Synthesis and Antioxidant Activity of Selenium Nanoparticles Using Theobroma cacao L. Bean Shell Extract

“…This probably is due to the increase of the free energy of the system that favours the aggregation of nanoparticles and, consequently, their stability is reduced. However, when the time was increased and the precursor amount decreased, SeNPs showed higher stability, which was attributed to a higher separation between the selenium nuclei thanks to the stabilizing agents present in CBSE, reducing the probability of aggregation during the formation of SeNPs [36,37,38].…”

Incorporation of Nonyl 3,4-Dihydroxybenzoate Into Nanostructured Lipid Systems: Effective Alternative for Maintaining Anti-Dermatophytic and Antibiofilm Activities and Reducing Toxicity at High Concentrations

“…Similar results were obtained by Medina-Alarcón et al (2017) with dodecyl protocatechuate in pneumocyte cell lines (MRC5) and human hepatoma cells (HepG2). In a similar study, Dananjaya et al (2018) investigated the antifungal activity and cytotoxicity of ZnO-chitosan (ZnO-C) nanocomposites against Candida albicans and in type 2 human epithelium cells (HEp-2), and observed that ZnO-C nanoparticles were able to decrease toxicity in these monolayers. Singh et al (2017) verified the toxicity of copper oxide nanoparticles and free copper oxide in human fibroblasts (HDF) and in human hepatoma cells (HepG2).…”