2015
DOI: 10.5155/eurjchem.6.4.461-467.1321 View full text |Buy / Rent full text
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Abstract: A series of six pyrazoline ring derivatives as a pharmacophore were incorporated to the naproxen; to increase its size were synthesized and preliminarly evaluated as antiinflammatory agents with expected selectivity toward COX-2 enzyme. In vivo acute antiinflammatory effects of the final compounds (5a-f) were evaluated in rats using egg-white induced edema model of inflammation. The tested compounds and the reference drug (naproxen) produced significant reduction of paw edema with respect to the effect of cont… Show more

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