Synthesis, characterization and modeling of self-assembled porphyrin nanorods

Laurencin, Danielle; Yot, Pascal G.; Gervais, Christel; Guari, Yannick; Clément, Sébastien; Elkaı̈m, Erik; Paillet, Matthieu; Cot, Didier; Richeter, Sébastien

doi:10.1142/s1088424619501451

Cited by 2 publications

(3 citation statements)

References 44 publications

(63 reference statements)

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“…The origin of this spectral evolution may be attributed either to the formation of porphyrin J-aggregates in the nanostructures or to the flattening of the porphyrin within the nanostructures inducing a larger π conjugation between the macrocycle and meso aryl groups. 38 Fluorescence spectra of the precursor 2 and nanoparticles are displayed in Figure 3d (λ exc = 430 nm). The two emission bands of porphyrins within nanoparticles at 664 and 732 nm are slightly red-shifted compared to those of the corresponding silylated porphyrin precursor (659 and 725 nm).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Compared with the porphyrin precursor, absorption bands of the porphyrins within nanoparticles are red-shifted. The origin of this spectral evolution may be attributed either to the formation of porphyrin J-aggregates in the nanostructures or to the flattening of the porphyrin within the nanostructures inducing a larger π conjugation between the macrocycle and meso aryl groups . Fluorescence spectra of the precursor 2 and nanoparticles are displayed in Figure d (λ exc = 430 nm).…”

Section: Resultsmentioning

confidence: 99%

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Periodic Mesoporous Ionosilica Nanoparticles for Green Light Photodynamic Therapy and Photochemical Internalization of siRNA

Mezghrani

Ali

Richeter

et al. 2021

ACS Appl. Mater. Interfaces

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We report Periodic Mesoporous Ionosilica Nanoparticles (PMINPs) as versatile nano-objects for imaging, photodynamic therapy (PDT), and efficient adsorption and delivery of siRNA into breast cancer cells. In order to endow these nanoparticles PDT and siRNA photochemical internalization (PCI) properties, a porphyrin derivative was integrated into the ionosilica framework. For this purpose, we synthesized PMINPs via hydrolysis-cocondensation procedures from oligosilylated ammonium and porphyrin precursors. The formation of these nanoobjects was attested by TEM. The formed nanoparticles were then thoroughly characterized via solid state NMR, nitrogen sorption, DLS, UV-Vis and fluorescence spectroscopy. Our results indicate the formation of highly porous nanorods with a length of 108 ± 9 nm and a width of 54 ± 4 nm. A significant PDT effect of type I mechanism (95 ± 2.8% of cell death) was observed upon green light irradiation in nanoparticles treated-breast cancer cells, while the blue light irradiation caused a significant phototoxic effect in non-treated cells. Furthermore, PMINPs formed stable complexes with siRNA (up to 24 h), which were efficiently internalized into the cells after 4 h of incubation mostly with energy-dependent endocytosis process. The PCI effect was obvious with green light irradiation and successfully led to 83 ± 1.1% silencing of luciferase gene in luciferase expressing breast cancer cells, while no gene silencing effect was observed with blue light irradiation. The present work highlights the high potential of porphyrin-doped PMINPs as multifunctional nanocarriers for nucleic acids, such as siRNA, with a triple ability to perform imaging, PDT and PCI.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Periodic Mesoporous Ionosilica Nanoparticles for Green Light Photodynamic Therapy and Photochemical Internalization of siRNA

Mezghrani

Ali

Richeter

et al. 2021

ACS Appl. Mater. Interfaces

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“…Porphyrins have significant applications in the electrochemical industry. Porphyrin derivatives, solid as well as liquid, have been used in fuel cells and solar cells and as catalysts in batteries for high-performance devices for the past few years. − Interestingly, porphyrins aggregate forming complex structures such as nanorods, nanotubes, nanorings, and so forth by stacking and other self-assembly methods. , Porphyrins are covalently bonded to each other forming a complex arrangement of covalent organic frameworks (COFs). The periodic boundary of each porphyrin is bonded to another by strong covalent bonds forming a new phase of advanced materials.…”

Section: Introductionmentioning

confidence: 99%

Quantum Chemical Support on the Two-Dimensional Assembly of Porphyrin Rings in the Application of Energy-Storage Devices

Suresh

Vijayakumar

2020

J. Phys. Chem. C

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Metal-ion batteries are the revolutionary gadgets of the present decade which still need improvement in efficiency and stability. Porphyrin, a common organic molecule, is considered in the present study for applications in solid-state physics. The organic molecule is covalently bonded to form a two-dimensional (2-D) sheet of covalent organic frameworks (COFs), and the stability and nature of the material are studied using density functional theory. We have investigated a 2-D sheet of porphyrin as an adsorbent for alkali metal ions, viz., Li + , Na + , and K + , using first principles study to be used as an electrode in batteries. The counterpoise method employed to investigate the adsorption of alkali metals at different sites of the porphyrin sheet (PS) shows that the Li + ion has strong affinity toward the sheet at the N site with a maximum energy of 109.9 kcal/mol and that the ability of absorbing Li clusters is much higher than that of individual Li + ions. The decrease in the highest occupied molecular orbital−lowest unoccupied molecular orbital gap confirms the strong affinity of alkali metals with the PS. The electron density difference plot establishes the charge accumulation and depletion on the PS when it interacts with alkali metals. The study detailed in the present manuscript strongly recommends porphyrin COFs as an electrode material for battery applications.

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Synthesis, characterization and modeling of self-assembled porphyrin nanorods

Cited by 2 publications

References 44 publications

Periodic Mesoporous Ionosilica Nanoparticles for Green Light Photodynamic Therapy and Photochemical Internalization of siRNA

Periodic Mesoporous Ionosilica Nanoparticles for Green Light Photodynamic Therapy and Photochemical Internalization of siRNA

Quantum Chemical Support on the Two-Dimensional Assembly of Porphyrin Rings in the Application of Energy-Storage Devices

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