Synthesis, characterization and in vitro studies of zinc and carbonate co-substituted nano-hydroxyapatite for biomedical applications

Kumar, G. Suresh; Thamizhavel, A.; Yokogawa, Yoshiyuki; Kalkura, S. Narayana; Girija, E. K.

doi:10.1016/j.matchemphys.2012.04.005

Cited by 115 publications

(61 citation statements)

References 60 publications

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“…The results of this study showed that because of the larger contact surface promoted by the presence of pores, there was more bone ingrowth on the implant-bone interface. Such results are consistent with those of Deporter et al [60], Karabuda et al [58] and Zinger et al [61] who also observed more effectiveness of the porous-surface implants compared to other types of implants.…”

Section: Histological Evaluation Of Ti Implant Samplessupporting

confidence: 92%

Surface Modification of Titanium Plate with Anodic Oxidation and Its Application in Bone Growth

Fadlallah¹,

Quahtany²,

El-Shenawy³

2013

JBNB

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Using implants for dental applications are well-accepted procedures as one of the solutions for periodontal defect repair. Suitable design and materials, their reaction with the surrounding hard tissues and interfacial biomechanical properties are still considered to be the primary criteria which need to be addressed. The purpose of present study was to evaluate the bone repair around pure titanium implants and porous surface using anodic oxidation technique, after their insertion in tibiae of rats (n = 15). Five animals received pure titanium-surface implants in tibia, 5 rough-surface implants (TiO 2 /Ti) in tibia and last five acted as control group. The interfacial integrity and compositional variation along the interface were studied using scanning electron microscope (SEM) with energy dispersive analysis of X-ray (EDX) and histopathology after 2 months. The rats were sacrificed 8 weeks after surgery and fragments of the tibiae containing the implants were submitted to histological analyses to evaluate new bone formation at the implant-bone interface as well as the tibiae were radio graphed. The SEM-EDX results confirmed the initial stability for the Ti implant, but the regeneration of new bone formation was faster in the case of TiO 2 /Ti implant, and hence could be used for faster healing. The results of the histological analysis showed that osseointegration occurred for both types of implants with similar quality of bone tissue. In conclusion, the porous-surface implants contributed to the osseointegration because they provide a larger contact area with surface roughness at implant-bone interface can help into the formation of physico-chemical bondage with the surrounding hard tissues.

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Section: Histological Evaluation Of Ti Implant Samplessupporting

confidence: 92%

Surface Modification of Titanium Plate with Anodic Oxidation and Its Application in Bone Growth

Fadlallah¹,

Quahtany²,

El-Shenawy³

2013

JBNB

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“…On the other hand, the lattice parameter a tends to decrease with Zn content up to 10 mol% Zn, while this parameter begins to increase for Zn higher concentrations [138,140,144].…”

Section: Influence Of Znmentioning

confidence: 94%

“…Zinc-substituted hydroxyapatite (Zn-HAp) has been produced by precipitation [49, [128][129][130][131][132][133][134][135][136][137][138] (at room temperature [128][129][130]134] [141][142][143].…”

Section: Synthesis Of Zn-substituted Hapmentioning

confidence: 99%

Cationic and Anionic Substitutions in Hydroxyapatite

Cacciotti¹

2016

Handbook of Bioceramics and Biocomposites

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“…The chemical composition of nHAp is complicated in reality, however the general chemical formula can be presented as formula given in the equation (1) [9]. (1) Precipitated or synthetic hydroxyapatite (sHAp) and calcium deficient hydroxyapatite (CDHAp) are also categorized as Non-Stoichiometric Hydroxyapatite due to formation of vacancies or incorporation of foreign cations or anions in the atomic structure of HAp [10,11].…”

Section: Introductionmentioning

confidence: 99%

Structural and morphological analysis of zinc incorporated non-stoichiometric hydroxyapatite nano powders

et al. 2016

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In this study, Zn incorporated non-stoichiometric hydroxyapatite (nHAp) was synthesized via precipitation method and effect of the incorporation of Zn (fraction: 2, 4, 6 and 8 mol-%) on the microstructure of nHAp was studied by XRD, FTIR analysis and SEM-EDS techniques. The formation of nHAp was confirmed by XRD and FTIR those showed that no secondary phase was formed through the Zn incorporation. The SEM studies also revealed that particles were formed in nano-metric size (30-60 nm). It was found that crystallite and particle size of Zn incorporated nHAp gradually decreased up to 6 mol-%, and started to increase while the Zn fraction reached up to the 8 mol-% and hence the morphology of the aggregated products was also changed. It can be concluded that the incorporation of Zn cations cause to form nHAp phase. Furthermore, the nHAp microstructure has deviated from stoichiometric condition by incorporation of more Zn cations.

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Synthesis, characterization and in vitro studies of zinc and carbonate co-substituted nano-hydroxyapatite for biomedical applications

Cited by 115 publications

References 60 publications

Surface Modification of Titanium Plate with Anodic Oxidation and Its Application in Bone Growth

Surface Modification of Titanium Plate with Anodic Oxidation and Its Application in Bone Growth

Cationic and Anionic Substitutions in Hydroxyapatite

Structural and morphological analysis of zinc incorporated non-stoichiometric hydroxyapatite nano powders

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