2010
DOI: 10.2147/ijn.s13482
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Abstract: Abstract:The purpose of this study was to develop a novel, highly water-soluble poly(L-γ-glutamyl-glutamine)-paclitaxel nanoconjugate (PGG-PTX) that would improve the therapeutic index of paclitaxel (PTX). PGG-PTX is a modification of poly(L-glutamic acid)-paclitaxel conjugate (PGA-PTX) in which an additional glutamic acid has been added to each glutamic side chain in the polymer. PGG-PTX has higher water-solubility and faster dissolution than PGA-PTX. Unlike PGA-PTX, PGG-PTX self-assembles into nanoparticles,… Show more

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Cited by 65 publications
(63 citation statements)
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“…Synthesis of the PGG-DTX conjugate was carried out following our previously published procedure 25 with the modification of replacing paclitaxel with DTX. Briefly, PGG-DTX was synthesized in a two-step process.…”
Section: Synthesis Of Pgg-dtx Conjugatementioning
confidence: 99%
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“…Synthesis of the PGG-DTX conjugate was carried out following our previously published procedure 25 with the modification of replacing paclitaxel with DTX. Briefly, PGG-DTX was synthesized in a two-step process.…”
Section: Synthesis Of Pgg-dtx Conjugatementioning
confidence: 99%
“…25 Briefly, 100 µL of cell suspension in culture medium at a concentration of 3 × 10 4 cells/mL was seeded in each well of a 96-well plate, and incubated at 37°C in a humidi- fied atmosphere with 5% CO 2 . After overnight incubation, serial dilutions of PGG-DTX were added to the plate (100 µL/well).…”
Section: In Vitro Cytotoxicity Assaymentioning
confidence: 99%
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“…Result confirmed that the maximum sustained dose of PGG-PTX was higher than the maximum sustained dose of the PGA-PTX and PGG-PTX was substantially higher than PGA-PTX. 36 The study concerning the therapeutic effect of a synthesized tricalcium phosphate (TCP) nanocomposite material (nano-TCP) on hepatocarcinoma in a rat model confirmed the safety and biodegradability of this nanocomposite. Results from the histopathological examination of liver tissues were compatible with the biochemical observation and confirmed …”
mentioning
confidence: 78%